|Tested species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide near C-terminus of human FOXP1.|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7.6, with 1% BSA|
|Contains||<0.1% sodium azide|
|Storage Conditions||4° C, do not freeze|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||1:100|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
Heat-mediated antigen retrieval is recommended prior to staining, using a 1mM EDTA buffer, pH 8.0, for 10 minutes followed by cooling at room temperature for 20 min. Following antigen retrieval, incubate samples with primary antibody for 10 min at room temperature. A suggested positive control is tonsil tissue.
Forkhead box (FOX) proteins are a group of 43 conserved transcription factors that are further divided into subgroups. The FOXP subgroup has four members, FOXP1 to FOXP4, which are widely expressed and contribute some critical roles in organ development, immune response, and cancer pathogenesis. FOXP1 is a transcriptional repressor that plays an important role in lung, cardiac valve, and B cell development. The FOXP1 gene is located on chromosome 3p14.1 and it may act as a tumor suppressor since the defect of FOXp1 gene was identified in multiple tumor types.
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