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Invitrogen

FOXP1 Polyclonal Antibody

View all (51) FOXP1 antibodies

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Product Details

PA5-85561

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:3,000
-

Immunohistochemistry (Paraffin) (IHC (P))

Assay-dependent
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein encompassing a sequence within the center region of human FOXP1. The exact sequence is proprietary.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7, with 20% glycerol

Contains

0.025% ProClin 300

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2792701

Product Specific Information

Keep as concentrated solution.

Predicted reactivity: Mouse (94%), Rat (97%), Chicken (91%), Rhesus Monkey (100%), Bovine (98%).

Positive Control: Raji, Raji nuclear extract, HeLa, HeLa nuclear extract.

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

This gene belongs to subfamily P of the forkhead box (FOX) transcription factor family. Forkhead box transcription factors play important roles in the regulation of tissue- and cell type-specific gene transcription during both development and adulthood. Forkhead box P1 protein contains both DNA-binding- and protein-protein binding-domains. This gene may act as a tumor suppressor as it is lost in several tumor types and maps to a chromosomal region (3p14.1) reported to contain a tumor suppressor gene(s). Alternative splicing results in multiple transcript variants encoding different isoforms.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: FLJ23741; Fork head related protein like B; fork head-related protein like B; Forkhead box protein P1; Forkhead box protein P1 (FOXP1); Forkhead-related transcription factor 1; FOXP1; Glutamine rich factor 1; glutamine-rich factor 1; Mac-1-regulated forkhead; MFH; MGC12942; MGC88572; MGC99551; unnamed protein product

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Gene Aliases: 12CC4; 3110052D19Rik; 4932443N09Rik; AI461938; AW494214; FOXP1; hFKH1B; HSPC215; MFH; QRF1

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UniProt ID: (Human) Q9H334, (Mouse) P58462

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Entrez Gene ID: (Human) 27086, (Mouse) 108655

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Function(s)
RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding core promoter sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding protein binding zinc ion binding identical protein binding sequence-specific DNA binding metal ion binding androgen receptor binding sequence-specific double-stranded DNA binding chromatin binding transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding protein homodimerization activity protein heterodimerization activity
Process(es)
negative regulation of transcription from RNA polymerase II promoter negative regulation of B cell apoptotic process regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter cellular response to DNA damage stimulus regulation of gene expression positive regulation of endothelial cell migration negative regulation of gene expression striatum development osteoclast differentiation forebrain development response to lipopolysaccharide regulation of interleukin-1 beta production regulation of interleukin-12 production regulation of tumor necrosis factor production positive regulation of interleukin-21 production response to testosterone osteoclast development macrophage activation monocyte activation endothelial cell activation regulation of monocyte differentiation negative regulation of transcription, DNA-templated animal organ development positive regulation of smooth muscle cell proliferation regulation of inflammatory response positive regulation of B cell receptor signaling pathway negative regulation of androgen receptor signaling pathway negative regulation of cell growth involved in cardiac muscle cell development T follicular helper cell differentiation cellular response to tumor necrosis factor regulation of defense response to bacterium regulation of macrophage colony-stimulating factor production positive regulation of hydrogen peroxide-mediated programmed cell death regulation of endothelial tube morphogenesis regulation of chemokine (C-X-C motif) ligand 2 production in utero embryonic development positive regulation of mesenchymal cell proliferation pre-B cell differentiation positive regulation of immunoglobulin production transcription, DNA-templated transcription from RNA polymerase II promoter heart development skeletal muscle tissue development motor neuron axon guidance anatomical structure morphogenesis embryo development lung development immunoglobulin V(D)J recombination sarcomere organization positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter smooth muscle tissue development positive regulation of epithelial cell proliferation cardiac muscle cell differentiation regulation of cardiac muscle cell proliferation lung secretory cell differentiation cardiovascular system development interleukin-21 secretion regulation of lung goblet cell differentiation negative regulation of lung goblet cell differentiation positive regulation of cardiac muscle cell differentiation
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