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This antibody is a rabbit polyclonal antibody raised against a peptide mapping within human FOXP3.
Immunogen sequence: AQCLLQREM VQSLEQQLVL EKEKLSAMQA HLAGKMALTK ASSVASSDKG SCCIVAAGSQ GPVVPAWSGP REAPDSLFAV RRHLWGSHGN STFPEFLHNM DYFKFHNMRP PFTYATLIRW AILEAPEKQR TLNEIYHWFT RMFAFFRNHP ATWKNAIRHN LSLHKCFVRV ESEKGAVWTV DELEFRKKRS QRPSRCSNPT PGP (230-431 aa encoded by BC113401)
FOXP3 (Forkhead box protein 3) is a member of the forkhead/winged-helix family of transcriptional regulators, highly conserved across mammals, and essential for normal immune homeostasis. FOXP3 is 381 amino acids long, stably and constitutively expressed at a high level in CD25 + CD4 positive regulatory T cells, a low level in CD4-positive/CD25-negative cells, and is absent in CD4-negative/CD8-positive T cells. FOXP3 may be a master regulatory gene, and a more specific marker of regulatory T cells. Defects in the gene encoding FOXP3 protein cause the scurfy phenotype in mice. In humans FOXP3 defects play a role in IPEX syndrome (immune dysfunction, polyendocrinopathy, enteropathy, X-linked syndrome), also known as X-linked autoimmunity-allergic dysregulation (XLAAD) syndrome. Transcript variants of FOXP3 encoding different isoforms have been identified. In human breast and colon cancer cells, expression of FOXP3 is regulated by p53 in response to the DNA damage.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Forkhead box protein P3; Forkhead box protein P3 41 kDa form; Forkhead box protein P3, C-terminally processed; FOXP3delta7; immune dysregulation, polyendocrinopathy, enteropathy, X-linked; immunodeficiency, polyendocrinopathy, enteropathy, X-linked; MGC141961; MGC141963; RP23-54C14.1; Scurfin; scurfy
Gene Aliases: FOXP3; IPEX; JM2