Suggested positive control: human liver protein, liver lysate.
Principal Names: Formyl Peptide receptor 1 (FPR1); fMet-Leu-Phe receptor (fMLP receptor); N-formylpeptide chemoattractant receptor; FMLP; Official Gene Symbol: FPR1 Gen Bank Accession Number: NP_002020 Gene ID: 2357 (Human) Gene Map Locus: 19q13.4 (Human) FPR1 is a member of chemoattractant/chemokine GPCRs expressed mainly on leukocytes, neutrophils and monocytes. FPR1 is a seven transmembrane pertussis toxin-sensitive GPCR and binds to formylated peptides generated by bacteria resulting in leukocyte trafficking to the site of inflammation. Ligand binding to FPR results in activation of multiple effectors including phospholipase C leading to calcium mobilization and PKC activation. Other implications of FPR signaling include polarization of actin cytoskeletion, activation of various integrins, increased cell migration, phagocytosis, degranulation and release of reactive oxygen intermediates.
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Protein Aliases: fMet-Leu-Phe receptor; fMLP receptor; FPR; FPR1; lipoxin A4 receptor; N-formyl peptide receptor; N-formylpeptide chemoattractant receptor
Gene Aliases: fMLF-R; FMLP; FPR; FPR1; LXA4R