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Proteintech
FRS2 Polyclonal Antibody
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Product Details
11503-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
FRS2 Fusion Protein Ag2052 (1-300 aa encoded by BC021562)
Conjugate
Form
Liquid
Concentration
0.22 mg/mL
Amount
33 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MGSCCSCPD KDTVPDNHRN KFKVINVDDD GNELGSGIME LTDTELILYT RKRDSVKWHY LCLRRYGYDS NLFSFESGRR CQTGQGIFAF KCARAEELFN MLQEIMQNNS INVVEEPVVE RNNHQTELEV PRTPRTPTTP GFAAQNLPNG YPRYPSFGDA SSHPSSRHPS VGSARLPSVG EESTHPLLVA EEQVHTYVNT TGVQEERKNR TSVHVPLEAR VSNAESSTPK EEPSSIEDRD PQILLEPEGV KFVLGPTPVQ KQLMEKEKLE QLGRDQVSGS GANNTEWDTG YDSDERRDAP S (1-300 aa encoded by BC021562)
Target Information
Adapter protein that links activated FGR and NGF receptors to downstream signaling pathways. Plays an important role in the activation of MAP kinases and in the phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, in response to ligand-mediated activation of FGFR1. Modulates signaling via SHC1 by competing for a common binding site on NTRK1. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: epididymis secretory sperm binding protein; FGFR signalling adaptor; FGFR substrate 2; FGFR-signaling adaptor SNT; Fibroblast growth factor receptor substrate 2; FRS2-alpha; SNT-1; SNT2; Suc1-associated neurotrophic factor target 1; unnamed protein product
Gene Aliases: 4732458E18; C330018A15Rik; FRS1A; FRS2; FRS2A; FRS2alpha; SNT; SNT-1; SNT1
UniProt ID: (Human) Q8WU20, (Mouse) Q8C180
Entrez Gene ID: (Human) 10818, (Mouse) 327826, (Rat) 314850
activation of MAPK activity
gastrulation with mouth forming second
organ induction
lens development in camera-type eye
ventricular septum development
transmembrane receptor protein tyrosine kinase signaling pathway
neuroblast proliferation
fibroblast growth factor receptor signaling pathway
anterior/posterior axis specification, embryo
positive regulation of signal transduction
forebrain development
regulation of apoptotic process
optic placode formation involved in camera-type eye formation
regulation of epithelial cell proliferation
prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis
lens fiber cell development
regulation of ERK1 and ERK2 cascade
transmembrane receptor protein tyrosine phosphatase signaling pathway
G-protein coupled receptor signaling pathway
positive regulation of MAPK cascade
negative regulation of cardiac muscle cell differentiation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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