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Proteintech
FSHR Polyclonal Antibody
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Product Details
22665-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse,
Sheep
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
FSHR Fusion Protein Ag18158 (18-352 aa encoded by BC118548)
Conjugate
Form
Liquid
Concentration
0.31 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: CHHRICHCS NRVFLCQESK VTEIPSDLPR NAIELRFVLT KLRVIQKGAF SGFGDLEKIE ISQNDVLEVI EADVFSNLPK LHEIRIEKAN NLLYINPEAF QNLPNLQYLL ISNTGIKHLP DVHKIHSLQK VLLDIQDNIN IHTIERNSFV GLSFESVILW LNKNGIQEIH NCAFNGTQLD ELNLSDNNNL EELPNDVFHG ASGPVILDIS RTRIHSLPSY GLENLKKLRA RSTYNLKKLP TLEKLVALME ASLTYPSHCC AFANWRRQIS ELHPICNKSI LRQEVDYMTQ TRGQRSSLAE DNESSYSRGF DMTYTEFDYD LCNEVVDVTC SPKPDA (18-352 aa encoded by BC118548)
Target Information
Follicle-Stimulating Hormone Receptor (FSHR) expression has been reported in ovary, uterus, and testis. ESTs have been isolated from testis libraries. G-protein Coupled Receptors (GPCRs) comprise one of the largest families of signaling molecules with more than a thousand members currently predicted to exist. All GPCRs share a structural motif consisting of seven membrane-spanning helices, and exist in both active and inactive forms. An array of activating ligands participate in the conformation of GPCRs which leads to signaling via G-proteins and downstream effectors. Ongoing studies have also shown the vast series of reactions which participate in the negative regulation of GPCRs. This turn-off activity has tremendous implications for the physiological action of the cell, and continues to drive pharmacological research for new drug candidates. Two blockbuster drugs which have been developed as GPCR-targeted pharmaceuticals are Zyprexa (Eli Lilly) and Claritin (Schering-Plough) which have multi-billion dollar shares of the mental health and allergy markets, respectively.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Follicle-stimulating hormone receptor; Follitropin receptor; FSH receptor; FSH-R
Gene Aliases: FSHR; FSHR1; FSHRO; LGR1; ODG1
UniProt ID: (Human) P23945, (Rat) P20395, (Mouse) P35378
Entrez Gene ID: (Human) 2492, (Rat) 25449, (Mouse) 14309
primary ovarian follicle growth
G-protein coupled receptor signaling pathway
adenylate cyclase-activating G-protein coupled receptor signaling pathway
activation of adenylate cyclase activity
spermatogenesis
female gamete generation
gonad development
male gonad development
female gonad development
hormone-mediated signaling pathway
regulation of protein kinase A signaling
positive regulation of phosphatidylinositol 3-kinase signaling
follicle-stimulating hormone signaling pathway
regulation of osteoclast differentiation
positive regulation of ERK1 and ERK2 cascade
ovarian follicle development
regulation of protein phosphorylation
regulation of systemic arterial blood pressure
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
phospholipase C-activating G-protein coupled receptor signaling pathway
spermatid development
locomotory behavior
cellular water homeostasis
regulation of platelet-derived growth factor receptor signaling pathway
ovulation cycle process
neuron projection development
regulation of hormone metabolic process
regulation of chromosome organization
regulation of intracellular estrogen receptor signaling pathway
positive regulation of intracellular estrogen receptor signaling pathway
sperm chromatin condensation
spermatogenesis, exchange of chromosomal proteins
regulation of MAPK cascade
transcytosis
negative regulation of bone resorption
Sertoli cell development
Sertoli cell proliferation
uterus development
regulation of acetylcholine metabolic process
basement membrane organization
signal transduction
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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