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Proteintech
FSHR Polyclonal Antibody, CoraLite® 488
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Product Details
CL488-22665
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
FSHR fusion protein Ag18158
Conjugate
Excitation/Emission Max
490/515 nm
Form
Liquid
Concentration
1000 µg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol, 0.5% BSA
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Sequence of this protein is as follows: CHHRICHCSN RVFLCQESKV TEIPSDLPRN AIELRFVLTK LRVIQKGAFS GFGDLEKIEI SQNDVLEVIE ADVFSNLPKL HEIRIEKANN LLYINPEAFQ NLPNLQYLLI SNTGIKHLPD VHKIHSLQKV LLDIQDNINI HTIERNSFVG LSFESVILWL NKNGIQEIHN CAFNGTQLDE LNLSDNNNLE ELPNDVFHGA SGPVILDISR TRIHSLPSYG LENLKKLRAR STYNLKKLPT LEKLVALMEA SLTYPSHCCA FANWRRQISE LHPICNKSIL RQEVDYMTQT RGQRSSLAED NESSYSRGFD MTYTEFDYDL CNEVVDVTCS PKPDA
Target Information
Follicle-Stimulating Hormone Receptor (FSHR) expression has been reported in ovary, uterus, and testis. ESTs have been isolated from testis libraries. G-protein Coupled Receptors (GPCRs) comprise one of the largest families of signaling molecules with more than a thousand members currently predicted to exist. All GPCRs share a structural motif consisting of seven membrane-spanning helices, and exist in both active and inactive forms. An array of activating ligands participate in the conformation of GPCRs which leads to signaling via G-proteins and downstream effectors. Ongoing studies have also shown the vast series of reactions which participate in the negative regulation of GPCRs. This turn-off activity has tremendous implications for the physiological action of the cell, and continues to drive pharmacological research for new drug candidates. Two blockbuster drugs which have been developed as GPCR-targeted pharmaceuticals are Zyprexa (Eli Lilly) and Claritin (Schering-Plough) which have multi-billion dollar shares of the mental health and allergy markets, respectively.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Follicle-stimulating hormone receptor; Follitropin receptor; FSH receptor; FSH-R
Gene Aliases: FSHR; FSHR1; FSHRO; LGR1; ODG1
UniProt ID: (Human) P23945
Entrez Gene ID: (Human) 2492
primary ovarian follicle growth
G-protein coupled receptor signaling pathway
adenylate cyclase-activating G-protein coupled receptor signaling pathway
activation of adenylate cyclase activity
spermatogenesis
female gamete generation
gonad development
male gonad development
female gonad development
hormone-mediated signaling pathway
regulation of protein kinase A signaling
positive regulation of phosphatidylinositol 3-kinase signaling
follicle-stimulating hormone signaling pathway
regulation of osteoclast differentiation
positive regulation of ERK1 and ERK2 cascade
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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