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Invitrogen

FSHR Polyclonal Antibody

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FSHR Polyclonal Antibody

Product Details

PA5-33547

Applications
Tested Dilution
Publications

Immunohistochemistry (Paraffin) (IHC (P))

10-20 µg/mL
-
Product Specifications

Species Reactivity

Human, Non-human primate

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic 17 amino acid peptide from N-terminal extracellular domain of human FSHR.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

50 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS

Contains

0.1% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2550927

Product Specific Information

Percent identity with other species by BLAST analysis: Human, Gorilla, Monkey, Marmoset (100%) Gibbon, Dog, Bat, Elephant, Rabbit, Horse, Pig, Guinea pig (94%).

Target Information

Follicle-Stimulating Hormone Receptor (FSHR) expression has been reported in ovary, uterus, and testis. ESTs have been isolated from testis libraries. G-protein Coupled Receptors (GPCRs) comprise one of the largest families of signaling molecules with more than a thousand members currently predicted to exist. All GPCRs share a structural motif consisting of seven membrane-spanning helices, and exist in both active and inactive forms. An array of activating ligands participate in the conformation of GPCRs which leads to signaling via G-proteins and downstream effectors. Ongoing studies have also shown the vast series of reactions which participate in the negative regulation of GPCRs. This turn-off activity has tremendous implications for the physiological action of the cell, and continues to drive pharmacological research for new drug candidates. Two blockbuster drugs which have been developed as GPCR-targeted pharmaceuticals are Zyprexa (Eli Lilly) and Claritin (Schering-Plough) which have multi-billion dollar shares of the mental health and allergy markets, respectively.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Follicle-stimulating hormone receptor; Follitropin receptor; FSH receptor; FSH-R; G-protein coupled receptor; FSHR; unnamed protein product

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Gene Aliases: FSHR; FSHR1; FSHRO; LGR1; ODG1

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UniProt ID: (Human) P23945

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Entrez Gene ID: (Human) 2492

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Function(s)
G-protein coupled receptor activity follicle-stimulating hormone receptor activity protein binding G-protein coupled peptide receptor activity protein-hormone receptor activity peptide hormone binding signaling receptor activity
Process(es)
ovarian follicle development primary ovarian follicle growth regulation of systemic arterial blood pressure signal transduction G-protein coupled receptor signaling pathway adenylate cyclase-modulating G-protein coupled receptor signaling pathway adenylate cyclase-activating G-protein coupled receptor signaling pathway adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway phospholipase C-activating G-protein coupled receptor signaling pathway spermatogenesis spermatid development female gamete generation locomotory behavior gonad development male gonad development female gonad development response to hormone hormone-mediated signaling pathway cellular water homeostasis regulation of platelet-derived growth factor receptor signaling pathway regulation of protein kinase A signaling ovulation cycle process neuron projection development regulation of hormone metabolic process regulation of chromosome organization regulation of intracellular estrogen receptor signaling pathway positive regulation of intracellular estrogen receptor signaling pathway sperm chromatin condensation follicle-stimulating hormone signaling pathway regulation of MAPK cascade transcytosis regulation of osteoclast differentiation negative regulation of bone resorption positive regulation of protein kinase B signaling Sertoli cell development Sertoli cell proliferation uterus development regulation of acetylcholine metabolic process positive regulation of ERK1 and ERK2 cascade cellular response to follicle-stimulating hormone stimulus basement membrane organization
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