This target displays homology in the following species: Cow: 93%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 77%
S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap2 2'-O-ribose methylation to the 5'-cap structure of mRNAs. Methylates the ribose of the second nucleotide of a m(7)GpppG-capped mRNA and small nuclear RNA (snRNA) (cap0) to produce m(7)GpppRmpNm (cap2). Recognizes a guanosine cap on RNA independently of its N(7) methylation status. Display cap2 methylation on both cap0 and cap1. Displays a preference for cap1 RNAs.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: adrift homolog; adrift-like; Cap methyltransferase 2; Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2; Cap2 2'O-ribose methyltransferase 2; FtsJ methyltransferase domain containing 1; FtsJ methyltransferase domain-containing protein 1; HMTr2; MTr2; Protein adrift homolog
Gene Aliases: AFT; AU022703; C730036L12Rik; CMTR2; FTSJD1; HMTr2; MTr2; RGD1309394; wu:fj48c05; zgc:55686