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FUBP1/2 Polyclonal Antibody
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FIGURE: 1 / 1
FUBP1/2 Antibody (BS-13224R) in IHC (P)
Paraformaldehyde-fixed, paraffin embedded Mouse intestine; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with FBP1 Polyclonal Antibody, Unconjugated (bs-13224R) at 1:200 overnight at 4°C, DAB staining.
Product Details
BS-13224R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human FUBP1.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
FUBP1 Regulates MYC expression by binding to a single-stranded far-upstream element (FUSE) upstream of the MYC promoter. May act both as activator and repressor of transcription. FUBP2 Binds to the dendritic targeting element and may play a role in mRNA trafficking. Part of a ternary complex that binds to the downstream control sequence (DCS) of the pre-mRNA. Mediates exon inclusion in transcripts that are subject to tissue-specific alternative splicing. May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly by recruiting degradation machinery to ARE-containing mRNAs.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DNA helicase V; epididymis secretory sperm binding protein; far upstream element (FUSE) binding protein 1; far upstream element (FUSE) binding protein 4; Far upstream element-binding protein 1; far upstream element-binding protein 1 {ECO:0000250|UniProtKB:Q96AE4, ECO:0000312|EMBL:AAI07943.1}; Far upstream element-binding protein 2; FBP; FBP {ECO:0000250|UniProtKB:Q96AE4}; fubp1 {ECO:0000312|EMBL:AAI07943.1, ECO:0000312|RGD:1591892}; FUSE binding protein 1; FUSE-binding protein 1; FUSE-binding protein 1 {ECO:0000250|UniProtKB:Q96AE4}; FUSE-binding protein 2; hDH V; KH type-splicing regulatory protein; KSRP; MAP2 RNA trans-acting protein 1; MAP2 RNA trans-acting protein MARTA1; p75; RNA binding protein; unnamed protein product
Gene Aliases: 6330409F21Rik; 9530027K12Rik; D3Ertd330e; FBP; FBP2; FUBP; FUBP1; FUBP2; Fubp4; hDH V; KHSRP; KSRP; Marta1; p75
UniProt ID: (Human) Q96AE4, (Rat) Q32PX7, (Mouse) Q91WJ8, (Human) Q92945, (Mouse) Q3U0V1
Entrez Gene ID: (Human) 8880, (Rat) 654496, (Mouse) 51886, (Human) 8570, (Rat) 171137, (Mouse) 16549
nucleic acid binding
DNA binding
single-stranded DNA binding
RNA binding
mRNA binding
protein binding
transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding
poly(A) RNA binding
mRNA 3'-UTR AU-rich region binding
protein binding involved in protein folding
mRNA 3'-UTR binding
RNA metabolism protein
regulation of transcription from RNA polymerase II promoter
regulation of gene expression
positive regulation of gene expression
transcription, DNA-templated
transcription from RNA polymerase II promoter
positive regulation of transcription from RNA polymerase II promoter
regulation of transcription, DNA-templated
RNA splicing, via transesterification reactions
mRNA processing
protein folding
RNA splicing
miRNA metabolic process
negative regulation of low-density lipoprotein particle clearance
regulation of mRNA stability
negative regulation of nitric oxide biosynthetic process
mRNA transport
positive regulation of mRNA catabolic process
3'-UTR-mediated mRNA destabilization
cellular response to cytokine stimulus
mRNA catabolic process
regulation of miRNA metabolic process
transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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