This Antibody was verified by KnockDown to ensure that the antibody binds to the antigen stated. View Details
Immunogen sequence: SSQSSYGQQS SYPGYGQQPA PSSTSGSYGS SSQSSSYGQP QSGSYSQQPS YGGQQQSYGQ QQSYNPPQGY GQQNQYNSSS GGGGGGGGGG NYGQDQSSMS SGGGSGGGYG NQDQSGGGGS GGYGQQDR
Highest antigen sequence identity to the following orthologs: Mouse - 91%, Rat - 91%.
FUS/TLS was originally described as fused in Sarcoma is actually related to a number of different cellular processes and correlated to several diseases. FUS binds DNA as a single or double strand, and acts as a site for transcription factors to recognize. Since FUS is well-documented to be involved in liposarcoma, lipoma and leukaemia, it is believed that when its normal housekeeping functions related to transcription are disrupted, normal cells become cancerous. Interestingly, FUS is also associated with the fatal neuron disorder amyotrophic lateral sclerosis; interruption of its normal RNA-binding functions leads to incorrect cellular localization and leads to pathologies of the neuron. Thus, FUS regulation of cellular functions is a critical component of maintenance of healthy cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 16) in malignant liposarcoma); 16) malignant liposarcoma; 75 kDa DNA-pairing protein; ALS6; fus-like protein; FUS1; fused in sarcoma; fusion (involved in t(12; fusion gene in myxoid liposarcoma; fusion, derived from t(12; fusion, derived from t(12;16) malignant liposarcoma; heterogeneous nuclear ribonucleoprotein P2; hnRNP P2; HNRNPP2; Oncogene FUS; Oncogene TLS; pigpen protein; POMP75; Protein pigpen; RNA-binding protein FUS; TLS; translocated in liposarcoma; Translocated in liposarcoma protein
Gene Aliases: ALS6; D430004D17Rik; D930039C12Rik; ETM4; FUS; FUS1; HNRNPP2; POMP75; TLS