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Proteintech
FUT11 Polyclonal Antibody
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Product Details
17175-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
FUT11 Fusion Protein Ag10815 (143-492 aa encoded by BC036037)
Conjugate
Form
Liquid
Concentration
0.16 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: ALLHEESPL NNFLLSHGPG IRLFNLTSTF SRHSDYPLSL QWLPGTAYLR RPVPPPMERA EWRRRGYAPL LYLQSHCDVP ADRDRYVREL MRHIPVDSYG KCLQNRELPT ARLQDTATAT TEDPELLAFL SRYKFHLALE NAICNDYMTE KLWRPMHLGA VPVYRGSPSV RDWMPNNHSV ILIDDFESPQ KLAEFIDFLD KNDEEYMKYL AYKQPGGITN QFLLDSLKHR EWGVNDPLLP NYLNGFECFV CDYELARLDA EKAHAASPGD SPVFEPHIAQ PSHMDCPVPT PGFGNVEEIP ENDSWKEMWL QDYWQGLDQG EALTAMIHNN ETEQTKFWDY LHEIFMKRQH L (143-492 aa encoded by BC036037)
Target Information
The FUT11 gene encodes for fructosyltransferase 11, an enzyme that is part of the glycosyltransferase family involved in the modification of glycoproteins and glycolipids by catalyzing the addition of fucose moieties. Enzymes like FUT11 play a critical role in the biosynthesis of Lewis antigen structures, significantly contributing to cell-cell adhesion, signal transduction, and immune recognition. Fucosylation, the process mediated by fructosyltransferases, is crucial for various biological functions, including the regulation of leukocyte trafficking and selectin binding, emphasizing its importance in immune responses and inflammation. While FUT11 is less characterized compared to other fucosyltransferases, altered expression patterns and functional abnormalities in these enzymes are linked to pathological conditions, such as cancer and inflammatory diseases, where changes in glycosylation can affect tumor progression, metastasis, and immune evasion. Ongoing research into FUT11 aims to elucidate its specific role in cellular processes and explore potential therapeutic applications by targeting fucosylation pathways to modify disease progression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: alpha (1,3) fucosyltransferase; Alpha-(1,3)-fucosyltransferase 11; alpha3-fucosyltransferase 11; EC 2.4.1; Fuc-TXI; Fucosyltransferase 11; fucosyltransferase 11 (alpha (1,3) fucosyltransferase); Fucosyltransferase XI; fucT-XI; Galactoside 3-L-fucosyltransferase 11; MGC119338; MGC119339; MGC33202
Gene Aliases: 3110009G03Rik; AI317183; FUT11
UniProt ID: (Human) Q495W5, (Mouse) Q8BHC9, (Rat) Q68FV3
Entrez Gene ID: (Human) 170384, (Mouse) 73068, (Rat) 286971
protein binding
alpha-(1->3)-fucosyltransferase activity
alpha-1,6-mannosyltransferase activity
alpha-1,2-mannosyltransferase activity
mannosyltransferase activity
alpha-1,3-mannosyltransferase activity
alpha-1,3-galactosyltransferase activity
molecular_function
UDP-glucose:glycoprotein glucosyltransferase activity
glycolipid mannosyltransferase activity
oligosaccharyl transferase activity
dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity
acetylglucosaminyltransferase activity
acetylgalactosaminyltransferase activity
galactosyltransferase activity
fucosyltransferase activity
O antigen polymerase activity
lipopolysaccharide-1,6-galactosyltransferase activity
transferase activity
transferase activity, transferring glycosyl groups
cellulose synthase activity
9-phenanthrol UDP-glucuronosyltransferase activity
1-phenanthrol glycosyltransferase activity
9-phenanthrol glycosyltransferase activity
1,2-dihydroxy-phenanthrene glycosyltransferase activity
phenanthrol glycosyltransferase activity
beta-1,4-mannosyltransferase activity
alpha-1,2-galactosyltransferase activity
dolichyl pyrophosphate Man7GlcNAc2 alpha-1,3-glucosyltransferase activity
lipopolysaccharide-1,5-galactosyltransferase activity
dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity
dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity
inositol phosphoceramide synthase activity
glucosyltransferase activity
alpha-(1->6)-fucosyltransferase activity
indole-3-butyrate beta-glucosyltransferase activity
salicylic acid glucosyltransferase (ester-forming) activity
salicylic acid glucosyltransferase (glucoside-forming) activity
benzoic acid glucosyltransferase activity
chondroitin hydrolase activity
dolichyl-pyrophosphate Man7GlcNAc2 alpha-1,6-mannosyltransferase activity
cytokinin 9-beta-glucosyltransferase activity
glycosyltransferase
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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