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Invitrogen
FUT11 Polyclonal Antibody
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FIGURE: 1 / 3
FUT11 Antibody (PA5-48094) in ICC/IF
Immunocytochemistry analysis of FUT11 was detected in immersion fixed NTera-2 human testicular embryonic carcinoma cell line. The cells were labeled with FUT11 Sheep Polyclonal Antibody (Product # PA5-48094) using a dilution of 10 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Anti-Sheep IgG Secondary Antibody (red, upper panel) counterstained with DAPI (blue, lower panel). Specific staining was localized to cytoplasm.
Product Details
PA5-48094
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Sheep
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
CHO-derived recombinant human Fucosyltransferase 11/FUT11 Gly25-Leu492
Conjugate
Form
Lyophilized
Concentration
0.2 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS with 5% trehalose
Contains
No Preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
In direct ELISAs, less than 1% cross-reactivity with recombinant human (rh) FUT3, rhFUT5, and rhFUT8 is observed.
Reconstitute at 0.2 mg/mL in sterile PBS.
Target Information
The FUT11 gene encodes for fructosyltransferase 11, an enzyme that is part of the glycosyltransferase family involved in the modification of glycoproteins and glycolipids by catalyzing the addition of fucose moieties. Enzymes like FUT11 play a critical role in the biosynthesis of Lewis antigen structures, significantly contributing to cell-cell adhesion, signal transduction, and immune recognition. Fucosylation, the process mediated by fructosyltransferases, is crucial for various biological functions, including the regulation of leukocyte trafficking and selectin binding, emphasizing its importance in immune responses and inflammation. While FUT11 is less characterized compared to other fucosyltransferases, altered expression patterns and functional abnormalities in these enzymes are linked to pathological conditions, such as cancer and inflammatory diseases, where changes in glycosylation can affect tumor progression, metastasis, and immune evasion. Ongoing research into FUT11 aims to elucidate its specific role in cellular processes and explore potential therapeutic applications by targeting fucosylation pathways to modify disease progression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: alpha (1,3) fucosyltransferase; Alpha-(1,3)-fucosyltransferase 11; EC 2.4.1; Fuc-TXI; Fucosyltransferase 11; Fucosyltransferase XI; fucT-XI; Galactoside 3-L-fucosyltransferase 11; GDP-fucose protein O-fucosyltransferase 4; MGC119338; MGC119339; MGC33202; unnamed protein product
Gene Aliases: FUCTXI; FUT11; POFUT4
UniProt ID: (Human) Q495W5
Entrez Gene ID: (Human) 170384
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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