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Invitrogen
FUT3 Polyclonal Antibody
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FIGURE: 1 / 3
FUT3 Antibody (PA5-101596) in IHC (P)
Immunohistochemistry analysis of FUT3 in human colorectal cancer. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with FUT3 polyclonal antibody (Product # PA5-101596) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.
Product Details
PA5-101596
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human FUT3(Accession P21217), corresponding to amino acid residues T94-Q144.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total FUT3.
Target Information
FUT3 comprises a set of fucosylated glycosphingolipids that are synthesized by exocrine epithelial cells and circulate in body fluids. The glycosphingolipids function in embryogenesis, tissue differentiation, tumor metastasis, inflammation, and bacterial adhesion. They are secondarily absorbed to red blood cells giving rise to their Lewis phenotype. This protein is a member of the fucosyltransferase family, which catalyzes the addition of fucose to precursor polysaccharides in the last step of Lewis antigen biosynthesis. It encodes an enzyme with alpha(1,3)-fucosyltransferase and alpha(1,4)-fucosyltransferase activities.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase 3; 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3; 4-fucosyltransferase; 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase; alpha-(1,3/1,4)-fucosyltransferase; Alpha-3-fucosyltransferase FUT3; Blood group Lewis alpha-4-fucosyltransferase; Fuc-TV; Fucosyltransferase 3; fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group); Fucosyltransferase III; FucT-III; FucT-V; galactoside 3(4)-L-fucosyltransferase; Lewis FT; Lewis Y; unnamed protein product
Gene Aliases: CD174; FT3B; FucT-III; FUT3; LE; Les
UniProt ID: (Human) P21217
Entrez Gene ID: (Human) 2525
protein binding
fucosyltransferase activity
transferase activity
transferase activity, transferring glycosyl groups
3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity
4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity
alpha-(1->3)-fucosyltransferase activity
protein glycosylation
protein N-linked glycosylation
protein O-linked glycosylation
lipid metabolic process
sphingolipid metabolic process
ceramide metabolic process
oligosaccharide metabolic process
oligosaccharide biosynthetic process
cell-cell recognition
positive regulation of cell-cell adhesion
regulation of cell migration
fucosylation
regulation of cell proliferation
macromolecule glycosylation
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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