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Invitrogen
FUT8 Polyclonal Antibody
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FIGURE: 1 / 3
FUT8 Antibody (PA5-47774) in IHC (P)
Immunohistochemical analysis of FUT8 in paraffin-embedded sections of human colon. Samples were incubated in FUT8 polyclonal antibody (Product # PA5-47774) using a dilution of 3 µg/mL overnight at 4 °C. Before incubation with the primary antibody tissue was subjected to heat-induced epitope retrieval using Antigen Retrieval Reagent-Basic. Tissue was stained using the Anti-Sheep HRP-DAB Cell & Tissue Stainin... View More
Product Details
PA5-47774
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Sheep
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
CHO-derived recombinant human Fucosyltransferase 8/FUT8 Asp32-Lys575
Conjugate
Form
Lyophilized
Concentration
0.2 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS with 5% trehalose
Contains
No Preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
In direct ELISAs, less than 1% cross-reactivity with recombinant human (rh) FUT3, rhFUT5, and rhFUT11 is observed.
Reconstitute at 0.2 mg/mL in sterile PBS.
Target Information
Alpha-(1,6)-fucosyltransferase (FUT8) is a gene located on chromosome 14q23.3, encoding an enzyme that catalyzes the addition of fucose to N-glycans via alpha-1,6-linkage. This fucosylation is important in modifying glycoproteins, influencing their function, stability, and interactions within biological systems. FUT8 activity is crucial in various physiological processes, including immune regulation, cell signaling, and development. Aberrant fucosylation patterns, due to altered FUT8 expression, have been associated with pathological conditions such as cancer and inflammatory diseases. In oncology, FUT8-mediated core fucosylation of glycoproteins is linked to tumor progression, metastasis, and therapeutic resistance, making it a potential biomarker for cancer diagnosis and prognosis. Additionally, FUT8's role in immune function highlights its involvement in cellular communication and homeostasis, offering insights into therapeutic strategies aimed at modulating glycosylation pathways to address disease states.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Alpha-(1,6)-fucosyltransferase; Alpha1-6FucT; EC 2.4.1.68; Fucosyltransferase 8; fucosyltransferase 8 (alpha (1,6) fucosyltransferase); GDP-fucose--glycoprotein fucosyltransferase; GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferase; Glycoprotein 6-alpha-L-fucosyltransferase; MGC26465; unnamed protein product
Gene Aliases: CDGF; CDGF1; FUT8
UniProt ID: (Human) Q9BYC5
Entrez Gene ID: (Human) 2530
in utero embryonic development
protein glycosylation
protein N-linked glycosylation
N-glycan processing
transforming growth factor beta receptor signaling pathway
integrin-mediated signaling pathway
respiratory gaseous exchange
oligosaccharide biosynthetic process
regulation of gene expression
fibroblast migration
cell migration
protein N-linked glycosylation via asparagine
viral protein processing
N-glycan fucosylation
L-fucose catabolic process
receptor metabolic process
GDP-L-fucose metabolic process
regulation of cellular response to oxidative stress
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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