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|Tested species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant fragment corresponding to a region within amino acids 65 and 296 of Human FVT1|
|Purification||Antigen affinity chromatography|
|Storage buffer||0.1M tris glycine, pH 7, with 20% glycerol|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Western Blot (WB)||1:500-1:3000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
PA5-31334 targets FVT1 in WB applications and shows reactivity with Human samples.
The PA5-31334 immunogen is recombinant fragment corresponding to a region within amino acids 65 and 296 of Human FVT1.
The protein encoded by this gene catalyzes the reduction of 3-ketodihydrosphingosine to dihydrosphingosine. The putative active site residues of the encoded protein are found on the cytosolic side of the endoplasmic reticulum membrane. A chromosomal rearrangement involving this gene is a cause of follicular lymphoma, also known as type II chronic lymphatic leukemia. The mutation of a conserved residue in the bovine ortholog causes spinal muscular atrophy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
3-dehydrosphinganine reductase; DHSR; follicular lymphoma variant translocation 1; follicular variant translocation protein 1; FVT-1; FVT1; KDS reductase; member 1; SDR35C1; short chain dehydrogenase/reductase family 35C; short chain dehydrogenase/reductase family 35C member 1; short chain dehydrogenase/reductase family 35C, member 1
DHSR; FVT1; KDSR; SDR35C1