PA1-334 detects FXR in mouse samples.
PA1-334 has been successfully used in Western blot procedures. By Western blot, this antibody detects an ~55 kDa protein representing FXR in mouse liver samples. An unknown band at ~60 kDa is also observed in western blots.
The PA1-334 immunogen is a synthetic peptide corresponding to residues R(224) K N V K Q H A D Q T V N E D(238) of mouse FXR. The PA1-334 immunizing peptide (Cat. # PEP-273) is available for use in neutralization and control experiments.
Farnesoid X-activated receptor (FXR), also known as the Bile acid receptor, is a member of the nuclear hormone receptor superfamily. FXR is involved in the regulation of bile acid metabolism. FXR forms a heterodimeric complex with the retinoic X receptor in the presence of a ligand. FXR is expressed primarily in liver and kidney.
The corresponding gene for the FXR is NR1H4.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Bile acid receptor; farnesoid X activated receptor; Farnesoid X-activated receptor; Farnesol receptor HRR-1; Nr1h4; Nuclear receptor subfamily 1 group H member 4; Retinoid X receptor-interacting protein 14; RXR-interacting protei; RXR-interacting protein 14
Gene Aliases: AI957360; Bar; Fxr; HRR1; Nr1h4; RIP14; Rxrip14
UniProt ID: (Mouse) Q60641
Entrez Gene ID: (Mouse) 20186