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FIGURE: 1 / 3
FXR1 Antibody (711442) in ICC/IF
For immunofluorescence analysis, A375 cells were fixed and permeabilized for detection of endogenous FXR1 using Anti-FXR1 Recombinant Rabbit Superclonal™ Antibody (Product # 711442, 2 µg/mL) and labeled with Goat anti-Rabbit IgG (Heavy Chain) Superclonal Secondary Antibody, Alexa Fluor® 488 conjugate (Product # A27034, 1:2000). Panel a) shows representative cells that were stained for detection and localization of FXR1 protein (green), Panel b) is stained for nuclei (blue) using SlowFade® Gold Antifade Mountant with DAPI (Product # S36938)... View More
Product Details
711442
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rhesus monkey,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
Expi293
Class
Recombinant Superclonal
Type
Antibody
Immunogen
Protein corresponding to Human FXR1 (aa 400-600)
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
Product Specific Information
This antibody is predicted to react with Monkey, Bovine and Sheep
Recombinant rabbit Superclonal™ antibodies are unique offerings from Thermo Fisher Scientific. They are comprised of a selection of multiple different recombinant monoclonal antibodies, providing the best of both worlds - the sensitivity of polyclonal antibodies with the specificity of monoclonal antibodies - all delivered with the consistency only found in a recombinant antibody. While functionally the same as a polyclonal antibody - recognizing multiple epitope sites on the target and producing higher detection sensitivity for low abundance targets - a recombinant rabbit Superclonal™ antibody has a known mixture of light and heavy chains. The exact population can be produced in every lot, circumventing the biological variability typically associated with polyclonal antibody production. Note: Formerly called “Recombinant polyclonal antibody”, this product is now rebranded as “Recombinant Superclonal™ antibody”. The physical product and the performance remain unchanged.
Target Information
FXR1 is an RNA binding protein that interacts with the functionally-similar proteins FMR1 and FXR2. It may regulate intracellular transport and local transltion of certain mRNAs. These proteins shuttle between the nucleus and cytoplasm and associate with polyribosomes, predominantly with the 60S ribosomal subunit. FXR1 is required for embryonic and postnatal development of muscle tissue. Three transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FMR1 autosomal homolog 1; FMR1 autosomal protein-like protein 1; fragile X mental retardation gene, autosomal homolog; fragile X mental retardation syndrome-related protein 1; fragile X mental retardation-related protein 1; fragile-X-related protein 1; FXR1P; hFXR1p; mFxr1p; RNA-binding protein FXR1; unnamed protein product
Gene Aliases: 1110050J02Rik; 9530073J07Rik; AI851072; CMYO9A; CMYO9B; CMYP9A; CMYP9B; FXR1; Fxr1h; FXR1P; MYOPMIL; MYORIBF
UniProt ID: (Human) P51114, (Rat) Q5XI81, (Mouse) Q61584
Entrez Gene ID: (Human) 8087, (Rhesus monkey) 710170, (Rat) 361927, (Mouse) 14359
nucleic acid binding
RNA binding
mRNA binding
mRNA 3'-UTR binding
protein binding
RNA strand annealing activity
mRNA 3'-UTR AU-rich region binding
protein homodimerization activity
ribonucleoprotein complex binding
translation regulator activity
protein heterodimerization activity
molecular condensate scaffold activity
G-quadruplex RNA binding
poly(A) RNA binding
translation factor
cytoplasmic translational initiation
regulation of translation
apoptotic process
spermatogenesis
spermatid development
muscle organ development
posttranscriptional regulation of gene expression
negative regulation of translation
dentate gyrus development
cell differentiation
negative regulation of tumor necrosis factor production
positive regulation of Rho protein signal transduction
regulation of mRNA stability
regulation of circadian sleep/wake cycle, sleep
positive regulation of translation
positive regulation of long-term neuronal synaptic plasticity
animal organ development
negative regulation of inflammatory response
regulation of neurogenesis
mRNA transport
nuclear pore complex assembly
nuclear pore localization
regulation of synaptic transmission, glutamatergic
skeletal muscle organ development
muscle structure development
mRNA destabilization
regulation of translation at presynapse, modulating synaptic transmission
membraneless organelle assembly
negative regulation of long-term synaptic potentiation
negative regulation of mRNA catabolic process
positive regulation of gene silencing by miRNA
multicellular organism development
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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