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Proteintech
FXYD2 Polyclonal Antibody
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Product Details
11198-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
FXYD2 Fusion Protein Ag1676 (1-66 aa encoded by BC013289)
Conjugate
Form
Liquid
Concentration
0.13 mg/mL
Amount
19.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
This antibody can recognize all three isoforms of FXYD2.
Immunogen sequence: MTGLSMDGG GSPKGDVDPF YYDYETVRNG GLIFAGLAFI VGLLILLSRR FRCGGNKKRR QINEDEP (1-66 aa encoded by B C013289)
Target Information
The human FXYD2 (pronounced fix-id) gene maps to chromosome 11q23 and encodes the gamma subunit of Na/K-ATPase (NKA). FXYD2 gamma subunit modulates NKA activity by inducing ion channel activity. The mammalian FXYD family maintains Na+ and K+ gradients between the intracellular and extracellular milieus of cells in processes such as renal Na+-reabsorption, muscle contraction and neuronal excitability. FXYDs are single-span membrane proteins that share a 35 amino acid signature domain, beginning with the sequence PFXYD and containing 7 invariant and 6 conserved amino acids. Other members of the FXYD family include FXYD1 (PLM, phospholemman), FXYD3 (Mat8, mammary tumor protein 8), FXYD4 (CHIF) and FXYD5 (RIC).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: ATPase, Na+/K+ transporting, gamma 1 polypeptide; FXTD domain-containing ion transport regulator 2; FXYD domain-containing ion transport regulator 2; gamma subunit of sodium potassium ATPase; Na(+)/K(+) ATPase subunit gamma; regulator 2; Sodium Potassium ATPase; Sodium pump gamma chain; sodium/potassium-transporting ATPase gamma chain; Sodium/potassium-transporting ATPase subunit gamma; unnamed protein product
Gene Aliases: ATP1C; ATP1G1; FXYD2; GNAKATP; HOMG2
UniProt ID: (Human) P54710, (Mouse) Q04646, (Rat) Q04679
Entrez Gene ID: (Human) 486, (Mouse) 11936, (Rat) 29639
ion transport
potassium ion transport
sodium ion transport
cellular sodium ion homeostasis
negative regulation of cell proliferation
establishment or maintenance of transmembrane electrochemical gradient
cellular potassium ion homeostasis
sodium ion export from cell
regulation of ion transport
transmembrane transport
cellular hyperosmotic salinity response
inorganic cation transmembrane transport
hydrogen ion transmembrane transport
positive regulation of sodium ion export from cell
potassium ion import across plasma membrane
transport
regulation of sodium ion transmembrane transporter activity
regulation of cell growth
sodium ion transmembrane transport
regulation of cell proliferation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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