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Invitrogen
FZD1 Polyclonal Antibody
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FIGURE: 1 / 1
FZD1 Antibody (PA5-47072) in IHC (F)
Immunohistochemical analysis of FZD1 in immersion fixed frozen sections of embryonic mouse intestine (13 d.p.c.). Samples were incubated in FZD1 polyclonal antibody (Product # PA5-47072) using a dilution of 15 µg/mL overnight at 4 °C. Tissue was stained with the Anti-Goat HRP-DAB Cell & Tissue Staining Kit (brown) and counterstained with hematoxylin (blue). Specific labeling was localized to the plasma memb... View More
Product Details
PA5-47072
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Mouse myeloma cell line NS0-derived recombinant mouse Frizzled-1 Gln72-His248 (Met122Ile)
Conjugate
Form
Lyophilized
Concentration
0.2 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS with 5% trehalose
Contains
No Preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
In direct ELISAs, less than 10% cross-reactivity with recombinant mouse (rm) Frizzled-2, rmFrizzled-4, rmFrizzled-7, and rmFrizzled-8 is observed, and less than 1% cross-reactivity with rmFrizzled-3 and rmFrizzled-6 is observed.
Reconstitute at 0.2 mg/mL in sterile PBS.
Target Information
Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD1 protein contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, 7 transmembrane domains, and a C-terminal PDZ domain-binding motif. The FZD1 transcript is expressed in various tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Chfz-1; Dfrizzled-1; DKFZp564G072; FLJ95923; frizzled; frizzled 1; Frizzled-1; Fz receptor 1; Fz-1; mFz1; Xfrizzled-1
Gene Aliases: AW227548; FZ-1; Fz1; Fzd1
UniProt ID: (Mouse) O70421
Entrez Gene ID: (Mouse) 14362
signal transducer activity
transmembrane signaling receptor activity
G-protein coupled receptor activity
receptor binding
frizzled binding
Wnt-protein binding
PDZ domain binding
identical protein binding
protein homodimerization activity
Wnt-activated receptor activity
protein heterodimerization activity
transmembrane signal receptor
positive regulation of protein phosphorylation
membranous septum morphogenesis
muscular septum morphogenesis
outflow tract morphogenesis
signal transduction
cell surface receptor signaling pathway
G-protein coupled receptor signaling pathway
cell-cell signaling
multicellular organism development
Wnt signaling pathway
negative regulation of BMP signaling pathway
epithelial cell differentiation
negative regulation of catenin import into nucleus
autocrine signaling
response to drug
canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation
canonical Wnt signaling pathway involved in osteoblast differentiation
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of sequence-specific DNA binding transcription factor activity
hard palate development
canonical Wnt signaling pathway
ventricular septum morphogenesis
negative regulation of canonical Wnt signaling pathway
planar cell polarity pathway involved in neural tube closure
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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