Invitrogen

FZD1 Polyclonal Antibody

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FZD1 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemical staining of mouse FZD1 in mouse intestine with FZD1 Polyclonal Antibody (Product # PA5-81392) (1:1000, formalin-fixed paraffin embedded sections). The left panel: tissue incubated with primary antibody; The right panel: tissue incubated with the mixture of primary antibody and antigen (recombinant protein).

Product Details

Applications

Tested Dilution

Publications

ELISA (ELISA)

1:1000-1:2000

-

Immunohistochemistry (Paraffin) (IHC (P))

1:500-1:2000

-

Product Specifications

Species Reactivity

Mouse

Host / Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant Mouse FZD1 protein

Conjugate

Unconjugated

Form

Liquid

Purification

Protein A, Antigen affinity chromatography

Storage buffer

PBS

Contains

no preservative

Storage conditions

Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C

RRID

AB_2788603

Product Specific Information

This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%).

This antibody has specificity for Mouse FZD1/Frizzled-1.

Target Information

Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD1 protein contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, 7 transmembrane domains, and a C-terminal PDZ domain-binding motif. The FZD1 transcript is expressed in various tissues.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Chfz-1; Dfrizzled-1; DKFZp564G072; FLJ95923; frizzled; frizzled 1; Frizzled-1; Fz receptor 1; Fz-1; mFz1; Xfrizzled-1

Gene Aliases: AW227548; FZ-1; Fz1; Fzd1

UniProt ID: (Mouse) O70421

Entrez Gene ID: (Mouse) 14362

Molecular Function: G-protein coupled receptor receptor signaling molecule

positive regulation of protein phosphorylation membranous septum morphogenesis muscular septum morphogenesis outflow tract morphogenesis signal transduction cell surface receptor signaling pathway G-protein coupled receptor signaling pathway cell-cell signaling multicellular organism development Wnt signaling pathway negative regulation of BMP signaling pathway epithelial cell differentiation negative regulation of catenin import into nucleus autocrine signaling response to drug canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation canonical Wnt signaling pathway involved in osteoblast differentiation negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of sequence-specific DNA binding transcription factor activity hard palate development canonical Wnt signaling pathway ventricular septum morphogenesis negative regulation of canonical Wnt signaling pathway planar cell polarity pathway involved in neural tube closure

Process(es)

signal transducer activity transmembrane signaling receptor activity G-protein coupled receptor activity receptor binding frizzled binding Wnt-protein binding PDZ domain binding identical protein binding protein homodimerization activity Wnt-activated receptor activity protein heterodimerization activity