Invitrogen

FZD1 Polyclonal Antibody

View all (12) FZD1 antibodies

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Questions & Answers

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FZD1 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemical staining of mouse FZD1 in mouse intestine with FZD1 Polyclonal Antibody (Product # PA5-81392, 1:1,000, formalin-fixed paraffin embedded sections). Left panel: tissue incubated with primary antibody. Right panel: tissue incubated with mixture of primary antibody and antigen (recombinant protein).

Product Details

PA5-81392

Applications	Tested Dilution	Publications
Immunohistochemistry (Paraffin) (IHC (P))	1:500-1:2,000	-
ELISA (ELISA)	1:1,000-1:2,000	-

Product Specifications
Species Reactivity	Mouse
Host/Isotype	Rabbit / IgG
Class	Polyclonal
Type	Antibody
Immunogen	Recombinant Mouse FZD1 protein View antigen
Conjugate	Unconjugated
Form	Liquid
Concentration	1 mg/mL
Purification	Protein A, Antigen affinity chromatography
Storage buffer	PBS
Contains	no preservative
Storage conditions	Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C
RRID	AB_2788603

Product Specific Information

This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%).

This antibody has specificity for Mouse FZD1/Frizzled-1.

Target Information

Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD1 protein contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, 7 transmembrane domains, and a C-terminal PDZ domain-binding motif. The FZD1 transcript is expressed in various tissues.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Chfz-1; Dfrizzled-1; DKFZp564G072; FLJ95923; frizzled; frizzled 1; Frizzled-1; Fz receptor 1; Fz-1; mFz1; Xfrizzled-1

Gene Aliases: AW227548; FZ-1; Fz1; Fzd1

UniProt ID: (Mouse) O70421

Entrez Gene ID: (Mouse) 14362

Molecular Function: transmembrane signal receptor

positive regulation of protein phosphorylation membranous septum morphogenesis muscular septum morphogenesis outflow tract morphogenesis signal transduction cell surface receptor signaling pathway G-protein coupled receptor signaling pathway cell-cell signaling multicellular organism development Wnt signaling pathway negative regulation of BMP signaling pathway epithelial cell differentiation negative regulation of catenin import into nucleus autocrine signaling response to drug canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation canonical Wnt signaling pathway involved in osteoblast differentiation negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of sequence-specific DNA binding transcription factor activity hard palate development canonical Wnt signaling pathway ventricular septum morphogenesis negative regulation of canonical Wnt signaling pathway planar cell polarity pathway involved in neural tube closure

Process(es)

signal transducer activity transmembrane signaling receptor activity G-protein coupled receptor activity receptor binding frizzled binding Wnt-protein binding PDZ domain binding identical protein binding protein homodimerization activity Wnt-activated receptor activity protein heterodimerization activity