Immunogen sequence: PDTLKCEKFP VHGAGELCVG QNTSDKGTPT PSLLPEFWTS NPQHGGGGHR GGFPGGAGAS ERGKFSCPRA LKVPSYLNYH FLGEKDCGAP CEPTKVYGLM YFGPEELRFS R; Positive Samples: Mouse eye, Mouse kidney, Mouse lung, Rat brain; Cellular Location: Cell membrane, Membrane, Multi-pass membrane protein
Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD1 protein contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, 7 transmembrane domains, and a C-terminal PDZ domain-binding motif. The FZD1 transcript is expressed in various tissues.
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Protein Aliases: Drosophila polarity gene (frizzled) homologue; Drosophila polarity gene homolog 1; frizzled 1, seven transmembrane spanning receptor; frizzled family receptor 1; frizzled homolog 1; frizzled, Drosophila, homolog of, 1; Frizzled-1; Fz-1; FzE1; hFz1; mFz1; rFz1; Wnt receptor
Gene Aliases: AW227548; FZ-1; Fz1; FZD1