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Invitrogen
FZD10 Polyclonal Antibody
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FIGURE: 1 / 4
FZD10 Antibody (PA5-75325) in IHC (P)
Immunohistochemistry analysis of FZD10 in paraffin-embedded human breast carcinoma tissue (cell membrane staining) and negative control (right, with PBS only). Samples were incubated with FZD10 polyclonal antibody (Product # PA5-75325) at a dilution of 1:50, followed by goat Anti-Rabbit IgG-biotin and avidin peroxidase.
Product Details
PA5-75325
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to amino acids 132-180 of Human FZD10.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Target Information
FZD10/Frizzled-10 is a 581 amino acid protein belonging to the G-protein coupled receptor Fz/Smo family and containing a signal peptide, a cysteine-rich domain in the N-terminal, seven transmembrane domains and a C-terminal PDZ domain-binding motif. It is involved in transduction, intercellular transmission of polarity information during tissue morphogenesis in differentiated tissues and as a receptor for Wnt proteins. FZD10 is expressed highly in placenta, fetal kidney, fetal lung, brain cerebellum, cerebral cortex, medulla and spinal cord with very low levels in total brain, frontal lobe, temporal lobe, putamen, adult brain, heart, lung and skeletal muscle.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD350; CD350 antigen; frizzled 10, seven transmembrane spanning receptor; frizzled family receptor 10; frizzled homolog 10; frizzled homolog 10, pseudogene 1; Frizzled-10; Fz-10; FzE7
Gene Aliases: CD350; FZ-10; Fz10; FZD10; Fzd10-ps1; FzE7; hFz10
UniProt ID: (Human) Q9ULW2, (Mouse) Q8BKG4
Entrez Gene ID: (Human) 11211, (Rat) 363913, (Mouse) 93897
signal transduction
cell surface receptor signaling pathway
G-protein coupled receptor signaling pathway
Wnt signaling pathway
neuron differentiation
regulation of actin cytoskeleton organization
non-canonical Wnt signaling pathway
positive regulation of JNK cascade
canonical Wnt signaling pathway
cellular response to retinoic acid
biological_process
non-canonical Wnt signaling pathway via JNK cascade
positive regulation of JUN kinase activity
multicellular organism development
negative regulation of GTPase activity
positive regulation of GTPase activity
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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