Search
Invitrogen
FZD4 Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
Product Details
PA5-33555
Product Specifications
Species Reactivity
Bovine,
Dog,
Hamster,
Human,
Non-human primate,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic 18 amino acid peptide from N-terminal extracellular domain of human FZD4 / Frizzled 4.
Conjugate
Form
Liquid
Concentration
0.4 mg/mL
Amount
50 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.1% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Percent identity with other species by BLAST analysis: Human, Gibbon, Monkey, Marmoset, Rat, Dolphin, Hamster, Elephant, Panda, Dog, Bovine (100%).
Target Information
FZD4 is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This protein may play a role as a positive regulator of the Wingless type MMTV integration site signaling pathway. A transcript variant retaining intronic sequence and encoding a shorter isoform has been described, however, its expression is not supported by other experimental evidence. Frizzled 4 is widely expressed, particularly in heart, skeletal muscle, ovary, and fetal kidney. Transcripts have also been identified in liver, kidney, pancreas, spleen, and fetal lung, and in smaller amounts in placenta, adult lung, prostate, testis, colon, and fetal brain.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: CD344; CD344 antigen; frizzled 4, seven transmembrane spanning receptor; frizzled class receptor 4; frizzled family receptor 4; frizzled homolog 4; frizzled receptor 4; Frizzled-4; frizzled-4-like protein; Fz-4; Fzd4; FzE4; G-protein coupled receptor; MGC34390; rFz4; unnamed protein product; WNT receptor frizzled-4
Gene Aliases: CD344; EVR1; FEVR; Frizzled-4; Fz-4; Fz4; FZD4; FZD4S; FzE4; GPCR; hFz4; I79_022172
UniProt ID: (Human) Q6S9E4, (Rat) Q9QZH0
Entrez Gene ID: (Dog) 485149, (Bovine) 445416, (Human) 8322, (Chinese hamster) 100756296, (Rat) 64558
beta-amyloid binding
transmembrane signaling receptor activity
cytokine receptor activity
G-protein coupled receptor activity
protein binding
Wnt-protein binding
cytokine binding
PDZ domain binding
ubiquitin protein ligase binding
signaling receptor activity
protein homodimerization activity
Wnt-activated receptor activity
macromolecular complex binding
protein heterodimerization activity
transmembrane signal receptor
angiogenesis
luteinization
blood vessel development
vasculogenesis
response to hypoxia
signal transduction
cell surface receptor signaling pathway
G-protein coupled receptor signaling pathway
Wnt signaling pathway, calcium modulating pathway
sensory perception of sound
cell proliferation
negative regulation of cell-substrate adhesion
Wnt signaling pathway
cytokine-mediated signaling pathway
neuron differentiation
positive regulation of cell migration
regulation of vascular endothelial growth factor receptor signaling pathway
locomotion involved in locomotory behavior
substrate adhesion-dependent cell spreading
extracellular matrix-cell signaling
non-canonical Wnt signaling pathway
progesterone secretion
endothelial cell differentiation
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of dendrite morphogenesis
canonical Wnt signaling pathway
establishment of blood-brain barrier
retina vasculature development in camera-type eye
retina vasculature morphogenesis in camera-type eye
cerebellum vasculature morphogenesis
retinal blood vessel morphogenesis
cellular response to retinoic acid
Norrin signaling pathway
positive regulation of neuron projection arborization
cellular response to leukemia inhibitory factor
biological_process
positive regulation of JUN kinase activity
positive regulation of sequence-specific DNA binding transcription factor activity
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support