Peptide sequence: GITSGMWIWS AKTLHTWQKC SNRLVNSGKV KREKRGNGWV KPGKGSETVV
Sequence homology: Cow: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rat: 100%
FZD4 is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This protein may play a role as a positive regulator of the Wingless type MMTV integration site signaling pathway. A transcript variant retaining intronic sequence and encoding a shorter isoform has been described, however, its expression is not supported by other experimental evidence. Frizzled 4 is widely expressed, particularly in heart, skeletal muscle, ovary, and fetal kidney. Transcripts have also been identified in liver, kidney, pancreas, spleen, and fetal lung, and in smaller amounts in placenta, adult lung, prostate, testis, colon, and fetal brain.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: CD344; EVR1; FEVR; frizzled 4, seven transmembrane spanning receptor; Frizzled family receptor 4; frizzled homolog 4; frizzled receptor 4; Frizzled-4; Fz-4; FZD4S; FzE4; GPCR; mFz4; MGC34390; rFz4; WNT receptor frizzled-4
Gene Aliases: BOS_24395; CD344; EVR1; FEVR; Fz-4; Fz4; FZD4; FZD4S; FzE4; GPCR; hFz4