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| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
1:500-1:1,000 | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Mouse |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
Synthetic peptide corresponding to residues M(1) R G P G T A A S H S P C(12) of mouse Frizzled. |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
1 mg/mL |
Purification |
Antigen affinity chromatography |
Storage buffer |
PBS |
Contains |
0.02% sodium azide |
Storage conditions |
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C |
RRID |
AB_2109395 |
PA1-4137 detects mouse frizzled.
PA1-4137 has been successfully used in Western blot procedures. By Western blot this antibody detects a ~40 kDa protein representing mouse fz in mouse pancreas lysate.
The PA1-4137 immunogen is a synthetic peptide corresponding to residues M(1) R G P G T A A S H S P C(12) of mouse Frizzled. This sequence is 91% conserved in rat.
Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif. FZD7 gene expression may downregulate APC function and enhance beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Frizzled-7; Fz-7; mFz7; rizzled 7
Gene Aliases: Fz7; Fzd7
UniProt ID: (Mouse) Q61090
Entrez Gene ID: (Mouse) 14369
Molecular Function:
transmembrane signal receptor
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