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| Applications | Tested Dilution | Publications |
|---|---|---|
Immunohistochemistry (Paraffin) (IHC (P)) |
15 µg/mL | - |
ELISA (ELISA) |
Assay-dependent | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Bovine, Hamster, Human, Mouse, Rabbit, Rat |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
Synthetic 18 amino acid peptide from C-terminus of human FZD7 / Frizzled 7. |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
1 mg/mL |
Purification |
Antigen affinity chromatography |
Storage buffer |
PBS |
Contains |
0.1% sodium azide |
Storage conditions |
Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C |
RRID |
AB_2550233 |
Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Mouse, Rat, Dog, Bovine, Bat, Hamster, Elephant, Panda, Rabbit, Opossum (100%); Platypus (94%); Chicken, Xenopus (89%).
For IHC(P), use heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen.
Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif. FZD7 gene expression may downregulate APC function and enhance beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: frizzled 7, seven transmembrane spanning receptor; frizzled class receptor 7; frizzled family receptor 7; frizzled homolog 7; Frizzled, drosophila, homolog of, 7; Frizzled-7; Fz-7; FzE3; hFz7; mFz7; rizzled 7
Gene Aliases: Frizzled-7; Fz7; FZD7; FzE3; I79_002993
UniProt ID: (Human) O75084, (Mouse) Q61090
Entrez Gene ID: (Human) 8324, (Rabbit) 103348917, (Bovine) 524255, (Mouse) 14369, (Chinese hamster) 100766658, (Rat) 100360552
Molecular Function:
transmembrane signal receptor
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