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Invitrogen
FZD8 Polyclonal Antibody
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Product Details
PA5-33562
Product Specifications
Species Reactivity
Bovine,
Dog,
Human,
Mouse,
Non-human primate,
Rabbit,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic 16 amino acid peptide from 3rd extracellular domain of human FZD8 / Frizzled 8.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.1% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Percent identity with other species by BLAST analysis: Human, Marmoset, Mouse, Rat, Elephant, Panda, Bovine, Dog, Rabbit, Opossum (100%) Lizard (94%) Monkey (81%).
Target Information
Members of the Frizzled family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. Frizzled 8 is highly expressed in two human cancer cell lines, indicating that it may play a role in several types of cancer. Its expression has been reported in brain, heart, kidney, pancreas, and skeletal muscle. ESTs have been isolated from embryo, eye, head/neck, heart, kidney, liver/spleen, pancreas, prostate, and testis libraries, as well as many tumor libraries. The crystal structure of the extracellular cysteine-rich domain of a similar mouse protein has been determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: frizzled 8, seven transmembrane spanning receptor; frizzled family receptor 8; frizzled homolog 8; Frizzled-8; Fz-8; HGNC:4046
Gene Aliases: FZ-8; Fz8; FZD8; hFZ8
UniProt ID: (Human) Q9H461, (Mouse) Q61091, (Rat) Q498S8
Entrez Gene ID: (Rabbit) 103352372, (Dog) 487073, (Human) 8325, (Mouse) 14370, (Rat) 364754
negative regulation of transcription from RNA polymerase II promoter
angiogenesis
G-protein coupled receptor signaling pathway
neuron differentiation
T cell differentiation in thymus
non-canonical Wnt signaling pathway
positive regulation of JUN kinase activity
positive regulation of transcription from RNA polymerase II promoter
canonical Wnt signaling pathway
positive regulation of protein phosphorylation
signal transduction
cell surface receptor signaling pathway
multicellular organism development
Wnt signaling pathway
biological_process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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