FIGURE: 1 / 1
Immunogen sequence: GSLYSDVSTG LTWRSGTASS VSYPKQMPLS QV
Highest antigen sequence identity to the following orthologs: Mouse - 100%, Rat - 100%.
Members of the Frizzled family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. Frizzled 8 is highly expressed in two human cancer cell lines, indicating that it may play a role in several types of cancer. Its expression has been reported in brain, heart, kidney, pancreas, and skeletal muscle. ESTs have been isolated from embryo, eye, head/neck, heart, kidney, liver/spleen, pancreas, prostate, and testis libraries, as well as many tumor libraries. The crystal structure of the extracellular cysteine-rich domain of a similar mouse protein has been determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: frizzled 8, seven transmembrane spanning receptor; frizzled family receptor 8; frizzled homolog 8; Frizzled-8; Fz-8; HGNC:4046
Gene Aliases: FZ-8; FZD8; hFZ8
UniProt ID: (Human) Q9H461
Entrez Gene ID: (Human) 8325
Molecular Function: transmembrane signal receptor