Invitrogen

FZR1 Polyclonal Antibody

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FZR1 Antibody in Western Blot (WB) — Western blot analysis of FZR1 in A431 whole cell and nuclear extracts using FZR1 polyclonal antibody (Product # PA5-85303) using 30 µg of sample at a dilution of 1:1000. Prior to incubation with primary antibody, the sample was separated on 10% SDS-PAGE.

FZR1 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry analysis of FZR1 in paraffin-embedded rat heart using FZR1 polyclonal antibody (Product # PA5-85303) at a dilution of 1:500.

FZR1 Antibody in Immunocytochemistry (ICC/IF) — Immunocytochemistry analysis of FZR1 in 4% paraformaldehyde-fixed HeLa cells using FZR1 polyclonal antibody (Product # PA5-85303) at a dilution of 1:500. Sample was then incubated with phalloidin secondary antibody at a dilution of 1:100.

Product Details

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:3000

Immunohistochemistry (Paraffin) (IHC (P))

1:100-1:1000

Immunocytochemistry (ICC/IF)

1:100-1:1000

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein encompassing a sequence within the center region of human FZR1.

Conjugate

Unconjugated

Form

Liquid

Concentration

0.26 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7, with 20% glycerol, 1% BSA

Contains

0.025% ProClin 300

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

RRID

AB_2792446

Product Specific Information

Keep as concentrated solution.

Predicted reactivity: Mouse (95%), Rat (95%), Xenopus laevis (90%), Pig (97%), Chicken (94%), Rhesus Monkey (100%), Bovine (97%).

Positive Control: A431, A431 nuclear extract.

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

FZR is a 7WD domain family member implicated in cell cycle regulation of Drosophila and yeast. It has been shown that the over expression of fzr proteins increases natural killer cell-mediated cell death and as a result, suppresses tumor growth. The fzr protein is essential for cyclosome activity.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: CDC20 homolog 1; CDC20-like 1b; CDC20-like protein 1; Cdh1/Hct1 homolog; cell division cycle 20 related 1; Fizzy-related protein homolog; Fzr; hCDH1

Gene Aliases: AW108046; CDC20C; CDH1; FYR; FZR; FZR1; FZR2; HCDH; HCDH1; KIAA1242

UniProt ID: (Human) Q9UM11, (Mouse) Q9R1K5

Entrez Gene ID: (Human) 51343, (Mouse) 56371, (Rat) 314642

Molecular Function: enzyme modulator