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Invitrogen
Factor VII Polyclonal Antibody
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FIGURE: 1 / 3
Factor VII Antibody (PA5-115207) in ICC/IF
Immunocytochemistry analysis of Factor VII in HeLa cells. Samples were treated with PFA, permeabilized in 0.1% Triton X-100, blocked in 10% serum (45 min at 25°C), and incubated with polyclonal antibody (Product # PA5-115207) at a dilution of 1:200 (1 hr at 37°C). Secondary staining was applied with mouse anti-beta tubulin; AlexaFluor 594 conjugated goat anti-rabbit IgG (Red); AlexaFluor 88 conjugated goat ... View More
Product Details
PA5-115207
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human F7(Accession P08709), corresponding to amino acid residues C187-L237.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total Factor VII.
Target Information
Coagulation factor VII is a vitamin K-dependent factor essential for hemostasis. This factor circulates in the blood in a zymogen form, and is converted to an active form by either factor IXa, factor Xa, factor XIIa, or thrombin by minor proteolysis. Upon activation of the factor VII, a heavy chain containing a catalytic domain and a light chain containing 2 EGF-like domains are generated, and two chains are held together by a disulfide bond. In the presence of factor III and calcium ions, the activated factor then further activates the coagulation cascade by converting factor IX to factor IXa and/or factor X to factor Xa. Defects in F7 production can cause coagulopathy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Coagulation factor VII; coagulation factor VII (serum prothrombin conversion accelerator); eptacog alfa; Factor 7; Factor7; FVII coagulation protein; Proconvertin; Serum prothrombin conversion accelerator; SPCA
Gene Aliases: AI132620; Cf7; F7; FVII; SPCA
UniProt ID: (Mouse) P70375, (Human) P08709, (Rat) Q8K3U6
Entrez Gene ID: (Mouse) 14068, (Human) 2155, (Rat) 260320
positive regulation of leukocyte chemotaxis
signal peptide processing
ER to Golgi vesicle-mediated transport
blood coagulation
blood coagulation, extrinsic pathway
circadian rhythm
positive regulation of platelet-derived growth factor receptor signaling pathway
response to organic cyclic compound
protein processing
peptidyl-glutamic acid carboxylation
positive regulation of blood coagulation
positive regulation of cell migration
organ regeneration
response to vitamin K
response to estrogen
positive regulation of positive chemotaxis
positive regulation of protein kinase B signaling
response to growth hormone
proteolysis
response to hormone
response to nutrient levels
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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