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Invitrogen
Factor XI Polyclonal Antibody
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Product Details
PA1-43048
Product Specifications
Species Reactivity
Human
Host/Isotype
Sheep
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Human Factor XI.
Conjugate
Form
Liquid
Concentration
12.4 mg/mL
Purification
SDS-PAGE
Storage buffer
50% water with 50% glycerol
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
PA1-43048 detects Factor XI in human samples.
PA1-43048 has successfully been used in Western blot and ELISA applications.
PA1-43048 was derived from human factor XI.
Target Information
This gene encodes coagulation factor XI of the blood coagulation cascade. This protein is present in plasma as a zymogen, which is a unique plasma coagulation enzyme because it exists as a homodimer consisting of two identical polypeptide chains linked by disulfide bonds. During activation of the plasma factor XI, an internal peptide bond is cleaved by factor XIIa (or XII) in each of the two chains, resulting in activated factor XIa, a serine protease composed of two heavy and two light chains held together by disulfide bonds. This activated plasma factor XI triggers the middle phase of the intrisic pathway of blood coagulation by activating factor IX. Defects in this factor lead to Rosenthal syndrome, a blood coagulation abnormality.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Coagulation factor XI; FXI; Plasma thromboplastin antecedent; PTA
Gene Aliases: F11; FXI
UniProt ID: (Human) P03951
Entrez Gene ID: (Human) 2160
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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