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Invitrogen
Factor XII Heavy chain Polyclonal Antibody
FIGURE: 1 / 1
Factor XII Heavy chain Antibody (PA5-76120) in WB
Western blot analysis of Factor XII Heavy chain in Lane 1: L02 whole cell lysate (40 µg), Lane 2: PC3 whole cell lysate (40 µg), Lane 3: AML-12 whole cell lysate (40 µg), Lane 4: PC12 whole cell lysate (40 µg). Samples were incubated with Factor XII Heavy chain polyclonal antibody (Product # PA5-76120) at a dilution of 1:500.
Product Details
PA5-76120
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant full length Human Factor XII Heavy chain (HC).
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2719847
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Target Information
Hemostasis following tissue injury involves the deployment of essential plasma procoagulants which are involved in a blood coagulation cascade leading to the formation of insoluble fibrin clots and the promotion of platelet aggregation. Factor XII, (FXII) a blood coagulation factor, is a serum glycoprotein that participates in fibrinolysis, as well as the generation of bradykinin and angiotensin. An enzyme of the serine protease (or serine endopeptidase) class, it activates both Factor XI and prekallikrein in the coagulation cascade. Factor XII deficiency, a rare hereditary disorder slightly more prevalent among Asians, does not cause excessive hemorrhaging since other coagulation factors compensate for it. Researchers have still reported Factor XII deficiency to be a risk factor for the development of arterial and venous thromboembolism. The gene for human Factor XII maps to the very end of the long arm of the fifth chromosome (5q33-qter).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: beta-factor XIIa part 1; beta-factor XIIa part 2; Coagulation factor XII; coagulation factor XII (Hageman factor); coagulation factor XIIa heavy chain; coagulation factor XIIa light chain; Factor 12; factor XII; Factor12; HAF; Hageman factor
Gene Aliases: F12; FXII; HAE3; HAEX; HAF
UniProt ID: (Human) P00748, (Rat) D3ZTE0, (Mouse) Q80YC5
Entrez Gene ID: (Human) 2161, (Rat) 306761, (Mouse) 58992
plasma kallikrein-kinin cascade
Factor XII activation
blood coagulation, intrinsic pathway
positive regulation of plasminogen activation
protein processing
protein autoprocessing
positive regulation of blood coagulation
zymogen activation
fibrinolysis
innate immune response
response to misfolded protein
positive regulation of fibrinolysis
proteolysis
blood coagulation
regulation of blood coagulation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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