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Product Details
61057
| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
1:500-1:5,000 | - |
Immunoprecipitation (IP) |
10 µL | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Human |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
This FancD2 antibody was raised against a peptide within the internal region of human FancD2. |
Conjugate |
Unconjugated |
Form |
Liquid |
Purification |
Antigen affinity chromatography |
Storage buffer |
70mM tris, pH 8, with 30% glycerol, 105mM NaCl, 0.07mM EDTA, 31mM glycine |
Contains |
0.035% sodium azide |
Storage conditions |
-20° C, Avoid Freeze/Thaw Cycles |
RRID |
AB_2793491 |
Target Information
FANCD2 (Fanconi anemia group D2 protein) is required for maintenance of chromosomal stability. It promotes accurate and efficient pairing of homologs during meiosis. FANCD2 is involved in the repair of DNA double-stranded breaks, both by homologous recombination and single-stranded annealing. It is required for the targeting/stabilization of BLM to non-centromeric abnormal structures induced by replicative stress. FANCD2 promotes BRCA2/FANCD1 loading onto damaged chromatin. Defects in the FANCD2 gene result in Fanconi anemia complementation group D2. This disorder affects all bone marrow elements resulting in anemia, leukopenia, and thrombopenia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DKFZp762A223; FACD2; Fanconi anemia group D2 protein; Fanconi anemia, complementation group D2; FLJ23826; Protein FACD2
Gene Aliases: FA-D2; FA4; FACD; FAD; FAD2; FANCD; FANCD2
UniProt ID: (Human) Q9BXW9
Entrez Gene ID: (Human) 2177
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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