Immunogen sequence: APHGPGLIYR QPNCDDPETE EAALVAIDYI NQNLPWGYKH TLNQIDEVKV WPQQPSGELF EIEIDTLETT CHVLDPTPVA RCSVRQLKEH AVEGDCDFQL LKLDGKFSVV YAKCDSSPDS AEDVRKVCQD CPLLAPLNDT RVVHAAKAAL AAFNAQNNGS NFQLEEISRA QLVPLPPSTY VEFTVSGTDC VAKEATEAAK CNLLAEKQYG FCKATLSEKL GGAEVAVTCM VFQTQPVSSQ PQPEGANEAV PTPVVDPDAP PSPPLGAPGL PPAGSPPDSH VL; Positive Samples: 293T, HepG2, DU145, A-549
Alpha2-HS glycoprotein (AHSG), a glycoprotein present in the serum, is synthesized by hepatocytes. The AHSG molecule consists of two polypeptide chains, which are both cleaved from a proprotein encoded from a single mRNA. It is involved in several functions, such as endocytosis, brain development and the formation of bone tissue. The protein is commonly present in the cortical plate of the immature cerebral cortex and bone marrow hemopoietic matrix, and it has therefore been postulated that it participates in the development of the tissues. However, its exact significance is still obscure.
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Protein Aliases: Alpha-2-HS-glycoprotein; Alpha-2-HS-glycoprotein chain A; Alpha-2-HS-glycoprotein chain B; Alpha-2-Z-globulin; Ba-alpha-2-glycoprotein; fetuin A; Fetuin-A; FetuinA
Gene Aliases: A2HS; AHS; AHSG; FETUA; HSGA; PRO2743
UniProt ID: (Human) P02765
Entrez Gene ID: (Human) 197
Molecular Function: protease inhibitor