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Bioss
Fibrillin 1 Polyclonal Antibody
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Product Details
BS-1157R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human FBN1, amino acids 401-500.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Fibrillin 1 is an extracellular acidic protein with a high cysteine content and an extended thread-like shape with mosaic composition of different types of extracellular modules. Most of the fibrillin molecule is contributed by 47 epidermal growth factor-like (EGF-like) repeats; 43 of them have a consensus sequence for calcium binding (cb). Other modules including 8-cysteine motifs (seven), hybrid motifs (two), and unique domains (three) are interspersed throughout the molecule[3-7]. Fibrillin 1 contains a proline-rich region close to the N-terminus that is replaced by a glycine-rich region in Fibrillin 2. The fibrillins are found throughout the connective tissue as integral components of extended fibrils.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: fibrillin 15; Fibrillin-1; tight skin
Gene Aliases: ACMICD; AI536462; B430209H23; ECTOL1; FBN; Fbn-1; FBN1; Fib-1; GPHYSD2; MASS; MFLS; MFS1; OCTD; SGS; SSKS; Tsk; WMS; WMS2
UniProt ID: (Human) P35555, (Mouse) Q61554
Entrez Gene ID: (Human) 2200, (Rat) 83727, (Mouse) 14118
skeletal system development
metanephros development
heart development
extracellular matrix disassembly
extracellular matrix organization
sequestering of BMP in extracellular matrix
sequestering of TGFbeta in extracellular matrix
camera-type eye development
embryonic eye morphogenesis
post-embryonic eye morphogenesis
cellular response to transforming growth factor beta stimulus
regulation of cellular response to growth factor stimulus
cellular response to insulin-like growth factor stimulus
kidney development
anatomical structure morphogenesis
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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