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Invitrogen
Fibrillin 1 Polyclonal Antibody
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FIGURE: 1 / 4
Fibrillin 1 Antibody (PA5-99225) in ICC/IF
Immunofluorescent analysis of Fibrillin 1 in HeLa cells. Samples were fixed with paraformaldehyde, permeabilized with 0.1% Triton X-100, blocked with 10% serum (45 min at 25°C), incubated with mouse anti-beta tubulin and Fibrillin 1 polyclonal antibody (Product # PA5-99225) using a dilution of 1:200 (1 hr, 37°C), and followed by goat anti-rabbit IgG Alexa Fluor 594 (red) and goat anti-mouse IgG Alexa Fluor ... View More
Product Details
PA5-99225
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human FBN1(Accession P35555), corresponding to amino acid residues V2823-H2871.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total Fibrillin 1.
Target Information
Fibrillin 1 is an extracellular acidic protein with a high cysteine content and an extended thread-like shape with mosaic composition of different types of extracellular modules. Most of the fibrillin molecule is contributed by 47 epidermal growth factor-like (EGF-like) repeats; 43 of them have a consensus sequence for calcium binding (cb). Other modules including 8-cysteine motifs (seven), hybrid motifs (two), and unique domains (three) are interspersed throughout the molecule[3-7]. Fibrillin 1 contains a proline-rich region close to the N-terminus that is replaced by a glycine-rich region in Fibrillin 2. The fibrillins are found throughout the connective tissue as integral components of extended fibrils.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: asprosin; epididymis secretory sperm binding protein; fibrillin 15; Fibrillin-1; fibrillin-1 preproprotein; tight skin; unnamed protein product
Gene Aliases: ACMICD; AI536462; B430209H23; ECTOL1; FBN; Fbn-1; FBN1; Fib-1; GPHYSD2; MASS; MFLS; MFS1; OCTD; SGS; SSKS; Tsk; WMS; WMS2
UniProt ID: (Human) P35555, (Mouse) Q61554
Entrez Gene ID: (Human) 2200, (Rat) 83727, (Mouse) 14118
integrin binding
hormone activity
extracellular matrix structural constituent
calcium ion binding
protein binding
heparin binding
extracellular matrix constituent conferring elasticity
identical protein binding
macromolecular complex binding
protein complex binding
extracellular matrix structural protein
skeletal system development
metanephros development
kidney development
glucose metabolic process
signal transduction
heart development
gene expression
protein kinase A signaling
lung development
positive regulation of appetite
cell adhesion mediated by integrin
activation of protein kinase A activity
sequestering of BMP in extracellular matrix
sequestering of TGFbeta in extracellular matrix
glucose homeostasis
camera-type eye development
negative regulation of osteoclast differentiation
embryonic eye morphogenesis
post-embryonic eye morphogenesis
lung alveolus development
cellular response to transforming growth factor beta stimulus
cellular response to insulin-like growth factor stimulus
negative regulation of osteoclast development
anatomical structure morphogenesis
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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