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Product Details
GAM-FBG
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Mouse fibrinogen
Conjugate
Form
Lyophilized
Storage buffer
whole serum
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitute the lyophilized antiserum by adding 1 mL sterile distilled water.
The antiSerum does not cross-react with any other component of Mouse plasma. Interspecies cross-reactivity is a normal feature of antibodies to plasma proteins since they frequently share antigenic determinants. Cross-reactivity of this antiSerum has not been tested in detail.
Target Information
Fibrinogen, the precursor of fibrin, is the coagulable protein in the blood plasma of vertebrates. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. Fibrinogen consists as a dimer of 3 pairs of non-identical chains FGA, FGB, and FGG that are cross-linked by disulfide bonds in their N-terminal segments. The molecule has 2 terminal D domains and one central E domain, all three domains are separated when fibrinogen is degradated by plasmin. Mutations in this gene lead to several disorders, including dysfibrinogenemia, afibrinogenemia, and renal amyloidosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: fibg; Fibrinogen alpha chain; Fibrinogen beta chain; Fibrinogen gamma chain; fibrinogen gamma-chain; fibrinogen, B beta polypeptide; fibrinogen, gamma polypeptide; gamma-fibrinogen; MGC119422; MGC119423; MGC119425
Gene Aliases: 2510049G14Rik; 3010002H13Rik; AI256424; ENSMUSG00000059807; Fga; Fgb; Fgg; Fib
UniProt ID: (Mouse) E9PV24, (Mouse) Q8K0E8, (Mouse) Q8VCM7
Entrez Gene ID: (Mouse) 14161, (Mouse) 110135, (Mouse) 99571
immune system process
cell-matrix adhesion
signal transduction
blood coagulation
hemostasis
platelet activation
positive regulation of heterotypic cell-cell adhesion
induction of bacterial agglutination
cellular protein complex assembly
innate immune response
positive regulation of vasoconstriction
positive regulation of exocytosis
positive regulation of protein secretion
protein polymerization
response to calcium ion
positive regulation of ERK1 and ERK2 cascade
platelet aggregation
positive regulation of peptide hormone secretion
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
negative regulation of endothelial cell apoptotic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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