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Invitrogen
Fibrinogen Polyclonal Antibody
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FIGURE: 1 / 3
Fibrinogen Antibody (PA1-26809) in IHC (P)
Immunohistochemistry (Paraffin) of Fibrinogen was performed in formalin fixed, paraffin embedded human liver tissue. The Fibrinogen Polyclonal Antibody (Product # PA1-26809) was used as a primary antibody at a dilution of 1:500 for 1 hour at room temperature, and a peroxidase goat antibody was used as a secondary at a dilution of 1:10,000 for 45 min at RT. Localization: Fibrinogen is localized in plasma. St... View More
Product Details
PA1-26809
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
C. elegans,
Human
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Fibrinogen collected from human plasma.
Conjugate
Form
Liquid
Concentration
90 mg/mL
Storage buffer
PBS, pH 7.2
Contains
0.01% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
Fibrinogen, the precursor of fibrin, is the coagulable protein in the blood plasma of vertebrates. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. Fibrinogen consists as a dimer of 3 pairs of non-identical chains FGA, FGB, and FGG that are cross-linked by disulfide bonds in their N-terminal segments. The molecule has 2 terminal D domains and one central E domain, all three domains are separated when fibrinogen is degradated by plasmin. Mutations in this gene lead to several disorders, including dysfibrinogenemia, afibrinogenemia, and renal amyloidosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: epididymis secretory sperm binding protein Li 78p; fibg; Fibrinogen alpha chain; Fibrinogen beta chain; Fibrinogen gamma chain; fibrinogen, A alpha polypeptide; fibrinogen, B beta polypeptide; fibrinogen, gamma polypeptide; MGC119422; MGC119423; MGC119425; testicular tissue protein Li 70
Gene Aliases: FGA; FGB; FGG; Fib2; HEL-S-78p; PRO2061
UniProt ID: (Human) P02671, (Human) P02675, (Human) P02679
Entrez Gene ID: (Human) 2243, (Human) 2244, (Human) 2266
adaptive immune response
platelet degranulation
protein complex assembly
acute-phase response
cell-matrix adhesion
signal transduction
blood coagulation
extracellular matrix organization
plasminogen activation
response to estradiol
response to genistein
positive regulation of heterotypic cell-cell adhesion
fibrinolysis
induction of bacterial agglutination
response to morphine
cellular protein complex assembly
cellular protein metabolic process
innate immune response
positive regulation of vasoconstriction
positive regulation of exocytosis
response to cycloheximide
positive regulation of protein secretion
protein polymerization
response to calcium ion
positive regulation of ERK1 and ERK2 cascade
platelet aggregation
cellular response to interleukin-6
cellular response to organic cyclic compound
blood coagulation, common pathway
blood coagulation, fibrin clot formation
positive regulation of peptide hormone secretion
liver regeneration
positive regulation of substrate adhesion-dependent cell spreading
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
cellular response to granulocyte colony-stimulating factor
negative regulation of endothelial cell apoptotic process
cellular response to leptin stimulus
cellular response to interleukin-1
protein secretion
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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