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OriGene
Fibronectin Polyclonal Antibody
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Product Details
TA590319
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
DNA immunization. This antibody is specific for the C Terminus Region of the target protein.
Conjugate
Form
Liquid
Concentration
1.03504 mg/mL
Amount
100 µg
Purification
Protein A/G
Storage buffer
PBS
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Fibronectin is a disulfide-bonded dimer with a molecular weight range of 230-250 kDa. In the extracellular matrix of several connective tissues and vessels, fibronectin is present as an insoluble protein that is extensively cross-linked by interchain disulfide bonds forming high molecular mass polymers. Fibronectin is most abundant during embryonic development and tissue remodeling. Fibronectin is also present at high concentrations as a soluble plasma protein. Fibronectin is organized as a linear series of repeating modules which form domains for interaction with fibronectin itself, other matrix components (e.g. collagen and heparin) and receptors on cells (e.g. integrins). Fibronectin is present in a soluble dimeric form in plasma, and in a dimeric or multimeric form at the cell surface and in extracellular matrix. Fibronectin is involved in cell adhesion and migration processes including embryogenesis, wound healing, blood coagulation, host defense, and metastasis. Fibronectin has been implicated in carcinoma development in lung cancer. Further, Fibronectin expression is increased especially in non-small cell lung carcinoma. The adhesion of lung carcinoma cells to Fibronectin enhances tumorgenecity and confers resistance to apoptosis induced by standard chemotherapeutic agents. The gene encoding Fibronectin has three regions subject to alternative splicing, with the potential to produce 20 different transcript variants. However, the full-length nature of some Fibronectin variants has not been determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CIG; Cold insoluble globulin (CIG); Cold-insoluble globulin; DKFZp686F10164; DKFZp686H0342; DKFZp686I1370; DKFZp686O13149; epididymis secretory sperm binding protein; extracellular matrix protein; ferritin L subunit; ferritin L-chain; Fibronectin; FN; lnc-ABCA12-8; Migration stimulating factor (MSF); migration-stimulating factor; unnamed protein product
Gene Aliases: CIG; ED-B; FINC; FN; FN1; FNZ; GFND; GFND2; LETS; MSF; SMDCF
UniProt ID: (Human) P02751
Entrez Gene ID: (Human) 2335
angiogenesis
regulation of protein phosphorylation
acute-phase response
cell-substrate junction assembly
cell adhesion
cell-matrix adhesion
calcium-independent cell-matrix adhesion
integrin-mediated signaling pathway
nervous system development
heart development
positive regulation of cell proliferation
regulation of cell shape
response to wounding
positive regulation of gene expression
response to muscle activity
integrin activation
substrate adhesion-dependent cell spreading
endodermal cell differentiation
wound healing
endothelial cell migration
positive regulation of axon extension
positive regulation of fibroblast proliferation
interaction with symbiont
positive regulation of protein kinase B signaling
regulation of ERK1 and ERK2 cascade
negative regulation of transforming growth factor beta production
blood coagulation, fibrin clot formation
negative regulation of monocyte activation
neural crest cell migration involved in autonomic nervous system development
positive regulation of substrate-dependent cell migration, cell attachment to substrate
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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