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Proteintech
Fibulin-1 Polyclonal Antibody
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Product Details
20425-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Fibulin-1 Fusion Protein Ag14249 (1-300 aa encoded by BC022497)
Conjugate
Form
Liquid
Concentration
0.24 mg/mL
Amount
36 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MERAAPSRR VPLQLLLLGG LALLAAGVDA DVLLEACCAD GHRMATHQKD CSLPYATESK ECRMVQEQCC HSQLEELHCA TGISLANEQD RCATPHGDNA SLEATFVKRC CHCCLLGRAA QAQGQSCEYS LMVGYQCGQV FRACCVKSQE TGDLDVGGLQ ETDKIIEVEE EQEDPYLNDR CRGGGPCKQQ CRDTGDEVVC SCFVGYQLLS DGVSCEDVNE CITGSHSCRL GESCINTVGS FRCQRDSSCG TGYELTEDNS CKDIDECESG IHNCLPDFIC QNTLGSFRCR PKLQCKSGFI Q (1-300 aa encoded by BC022497)
Target Information
Fibulin-1 is a modular glycoprotein component of the elastic extracellular matrix fibers, basement membranes and blood. Fibulin-1 self associates as well as binds to calcium, fibronectin, laminin, nidogen and fibrinogen. These interactions, individually or in combination, may account for the observed association of Fibulin-1 with basement membranes, connective tissue, elastic fibers and fibrin clots. Fibulin-1 expression is stimulated by estrogen in ovarian cancer cell lines and has been suggested as both an agent of metastasis in ovarian cancer cells and an indicator for predicting cancer risk or aggressiveness in ovarian carcinomas. Other studies point to the inhibition of cancer cell motility with increasing exposure to Fibulin-1. The exact function of Fibulin-1 in the cell is unknown.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Basement-membrane protein 90; BM-90; BM-90/fibulin extracellular matrix glyroprotein; FIBL-1; Fibulin-1; Fibulin1; unnamed protein product
Gene Aliases: FBLN; FBLN1; FIBL1; PP213
UniProt ID: (Human) P23142, (Mouse) Q08879
Entrez Gene ID: (Human) 2192, (Rat) 315191, (Mouse) 14114
negative regulation of protein phosphorylation
negative regulation of cell adhesion
integrin-mediated signaling pathway
embryo implantation
positive regulation of gene expression
extracellular matrix organization
positive regulation of fibroblast proliferation
negative regulation of ERK1 and ERK2 cascade
negative regulation of transforming growth factor beta production
blood coagulation, fibrin clot formation
negative regulation of substrate adhesion-dependent cell spreading
negative regulation of transformation of host cell by virus
positive regulation of substrate-dependent cell migration, cell attachment to substrate
negative regulation of cell motility
negative regulation of stem cell proliferation
positive regulation of peptidase activity
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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