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Invitrogen
Ficolin 3 Polyclonal Antibody
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Product Details
PA5-42017
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide directed towards the N-terminal of human FCN3 (aa 35-84).
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
50 µg
Purification
Affinity Chromatography
Storage buffer
PBS with 2% sucrose
Contains
0.09% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Peptide sequence: LEASKVVLLP SCPGAPGSPG EKGAPGPQGP PGPPGKMGPK GEPGDPVNLL
Sequence homology: Cow: 91%; Dog: 79%; Guinea Pig: 77%; Horse: 100%; Human: 100%; Mouse: 91%; Pig: 91%; Rabbit: 79%; Rat: 100%; Zebrafish: 92%
Target Information
H-Ficolin (Hakata antigen, Ficolin-3) is an innate immunity pattern recognition molecule found in human serum. H-Ficolin binds to distinct pathogen-associated molecular patterns (PAMP) formed by carbohydrates (GlcNAc, GalNAc and fucose) activating complement through the lectin pathway by means of the associated MASPs ((MBL)-associated serine proteases). H-Ficolin consists of 35 kDa protein chains associated in triplet subunits which are again associated in high molecular weight oligomers by means of disulfide bonds at the N-terminal region.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Collagen/fibrinogen domain-containing lectin 3 p35; Collagen/fibrinogen domain-containing protein 3; FCN3; ficolin (collagen/fibrinogen domain containing) 3 (Hakata antigen); Ficolin-3; H-ficolin; Hakata antigen; MGC22543; unnamed protein product
Gene Aliases: FCN3; FCNH; HAKA1
UniProt ID: (Human) O75636
Entrez Gene ID: (Human) 8547
complement activation, lectin pathway
activation of membrane attack complex
immune system process
cell surface pattern recognition receptor signaling pathway
proteolysis
complement activation
opsonization
zymogen activation
killing of cells of other organism
recognition of apoptotic cell
innate immune response
negative regulation of viral entry into host cell
protein maturation
defense response to virus
negative regulation of RNA biosynthetic process
positive regulation of opsonization
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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