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Bethyl Laboratories

Filamin A Polyclonal Antibody

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Filamin A Polyclonal Antibody

Product Details

IHC-00225

Applications
Tested Dilution
Publications

Immunohistochemistry (IHC)

1:50-1:500
-

Immunohistochemistry (Paraffin) (IHC (P))

1:100-1:500
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Region between residue 1725 and 1775 of human Filamin A.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

50 µg/mL

Amount

5 µg

Purification

Antigen affinity chromatography

Storage buffer

TBS, pH 7.0 to 8.0, with 0.1% BSA

Contains

0.09% sodium azide

Storage conditions

4°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

The recommended shelf life for this product is 1 year from date of receipt.

Based on 100% sequence identity, this antibody is predicted to react with Mouse, Orangutan, Monkey, Gorilla, Northern white-cheeked gibbon, Olive baboon, Crab-eating macaque and Dusky titi monkey

Target Information

Filamin functions as a crosslinking protein forming a flexible link between two actin filaments. It is composed of two identical polypeptide chains each joined to the other at one end, with an actin binding site at the other. It is present in human platelets, lymphocytes, fibroblasts and smooth muscle actin.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: ABP-280; actin binding protein 280; Actin-binding protein 280; Alpha-filamin; Endothelial actin-binding protein; epididymis secretory sperm binding protein; filamin 1; filamin A, alpha; Filamin-1; Filamin-A; Filamin1; FilaminA; FLN-A; Non-muscle filamin; unnamed protein product

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Gene Aliases: ABP-280; ABPX; CSBS; CVD1; FGS2; FLN; FLN-A; FLN1; FLNA; FMD; MNS; NHBP; OPD; OPD1; OPD2; XLVD; XMVD

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UniProt ID: (Human) P21333

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Entrez Gene ID: (Human) 2316

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Function(s)
G-protein coupled receptor binding RNA binding actin binding protein binding potassium channel regulator activity kinase binding small GTPase binding Fc-gamma receptor I complex binding protein homodimerization activity ion channel binding macromolecular complex binding cadherin binding SMAD binding actin filament binding GTPase binding DNA-binding transcription factor binding protein sequestering activity
Process(es)
adenylate cyclase-inhibiting dopamine receptor signaling pathway blood coagulation, intrinsic pathway positive regulation of platelet activation negative regulation of transcription from RNA polymerase I promoter formation of radial glial scaffolds cerebral cortex development cell projection organization actin cytoskeleton organization regulation of cell migration positive regulation of actin filament bundle assembly protein localization to cell surface megakaryocyte development negative regulation of protein catabolic process positive regulation of protein import into nucleus mRNA transcription from RNA polymerase II promoter negative regulation of apoptotic process receptor clustering positive regulation of I-kappaB kinase/NF-kappaB signaling negative regulation of sequence-specific DNA binding transcription factor activity wound healing, spreading of cells establishment of protein localization protein stabilization release of sequestered calcium ion into cytosol actin crosslink formation cilium morphogenesis platelet aggregation semaphorin-plexin signaling pathway protein localization to plasma membrane tubulin deacetylation mitotic spindle assembly establishment of Sertoli cell barrier positive regulation of substrate adhesion-dependent cell spreading positive regulation of potassium ion transmembrane transport protein localization to bicellular tight junction regulation of membrane repolarization during atrial cardiac muscle cell action potential regulation of membrane repolarization during cardiac muscle cell action potential positive regulation of neural precursor cell proliferation positive regulation of integrin-mediated signaling pathway positive regulation of neuron migration
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