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Bethyl Laboratories
Filamin A Polyclonal Antibody
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FIGURE: 1 / 4
Filamin A Antibody (IHC-00225) in IHC (P)
Detection of human Filamin by immunohistochemistry. Sample: FFPE section of human colon carcinoma. Antibody: Affinity purified rabbit anti-Filamin (Product # IHC-00225) used at a dilution of 1:100. Detection: Red-fluorescent Alexa Fluor® 555 goat anti-rabbit IgG (Invitrogen) used at a dilution of 1:500.
Product Details
IHC-00225
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Region between residue 1725 and 1775 of human Filamin A.
Conjugate
Form
Liquid
Concentration
50 µg/mL
Amount
5 µg
Purification
Antigen affinity chromatography
Storage buffer
TBS, pH 7.0 to 8.0, with 0.1% BSA
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Based on 100% sequence identity, this antibody is predicted to react with Mouse, Orangutan, Monkey, Gorilla, Northern white-cheeked gibbon, Olive baboon, Crab-eating macaque and Dusky titi monkey
Target Information
Filamin functions as a crosslinking protein forming a flexible link between two actin filaments. It is composed of two identical polypeptide chains each joined to the other at one end, with an actin binding site at the other. It is present in human platelets, lymphocytes, fibroblasts and smooth muscle actin.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ABP-280; actin binding protein 280; Actin-binding protein 280; Alpha-filamin; Endothelial actin-binding protein; epididymis secretory sperm binding protein; filamin 1; filamin A, alpha; Filamin-1; Filamin-A; Filamin1; FilaminA; FLN-A; Non-muscle filamin; unnamed protein product
Gene Aliases: ABP-280; ABPX; CSBS; CVD1; FGS2; FLN; FLN-A; FLN1; FLNA; FMD; MNS; NHBP; OPD; OPD1; OPD2; XLVD; XMVD
UniProt ID: (Human) P21333
Entrez Gene ID: (Human) 2316
G-protein coupled receptor binding
RNA binding
actin binding
protein binding
potassium channel regulator activity
kinase binding
small GTPase binding
Fc-gamma receptor I complex binding
protein homodimerization activity
ion channel binding
macromolecular complex binding
cadherin binding
SMAD binding
actin filament binding
GTPase binding
DNA-binding transcription factor binding
protein sequestering activity
adenylate cyclase-inhibiting dopamine receptor signaling pathway
blood coagulation, intrinsic pathway
positive regulation of platelet activation
negative regulation of transcription from RNA polymerase I promoter
formation of radial glial scaffolds
cerebral cortex development
cell projection organization
actin cytoskeleton organization
regulation of cell migration
positive regulation of actin filament bundle assembly
protein localization to cell surface
megakaryocyte development
negative regulation of protein catabolic process
positive regulation of protein import into nucleus
mRNA transcription from RNA polymerase II promoter
negative regulation of apoptotic process
receptor clustering
positive regulation of I-kappaB kinase/NF-kappaB signaling
negative regulation of sequence-specific DNA binding transcription factor activity
wound healing, spreading of cells
establishment of protein localization
protein stabilization
release of sequestered calcium ion into cytosol
actin crosslink formation
cilium morphogenesis
platelet aggregation
semaphorin-plexin signaling pathway
protein localization to plasma membrane
tubulin deacetylation
mitotic spindle assembly
establishment of Sertoli cell barrier
positive regulation of substrate adhesion-dependent cell spreading
positive regulation of potassium ion transmembrane transport
protein localization to bicellular tight junction
regulation of membrane repolarization during atrial cardiac muscle cell action potential
regulation of membrane repolarization during cardiac muscle cell action potential
positive regulation of neural precursor cell proliferation
positive regulation of integrin-mediated signaling pathway
positive regulation of neuron migration
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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