Search
Invitrogen
Filamin A Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
FIGURE: 1 / 7
Filamin A Antibody (PA5-86143) in ICC/IF
Immunofluorescence analysis of Filamin A in 3T3-L1 cells. Sample was incubated with polyclonal Filamin A antibody (Product # PA5-86143) using a 1:100 dilution, and followed by goat anti-rabbit IgG (H+L)-FITC and Hoechst (nuclei staining) secondary antibodies at a dilution of 1:200.
Product Details
PA5-86143
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide, corresponding to amino acids 2100-2200 of Human Filamin 1.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Purity is > 95% by SDS-PAGE.
Target Information
Filamin functions as a crosslinking protein forming a flexible link between two actin filaments. It is composed of two identical polypeptide chains each joined to the other at one end, with an actin binding site at the other. It is present in human platelets, lymphocytes, fibroblasts and smooth muscle actin.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: ABP-280; actin binding protein 280; Actin-binding protein 280; Alpha-filamin; dilated pupils 2; Endothelial actin-binding protein; Endothelial actin-binding protein 280); epididymis secretory sperm binding protein; filamin 1; filamin A, alpha; filamin, alpha; Filamin-1; Filamin-A; Filamin1; FilaminA; FLN-A; Non-muscle filamin; unnamed protein product
Gene Aliases: ABP-280; ABPX; CSBS; CVD1; Dilp2; F730004A14Rik; FGS2; filamin-1; FLN; FLN-A; FLN1; FLNA; FMD; GENA 379; MNS; NHBP; OPD; OPD1; OPD2; RGD1560614; XLVD; XMVD
UniProt ID: (Human) P21333, (Mouse) Q8BTM8
Entrez Gene ID: (Human) 2316, (Rat) 293860, (Mouse) 192176
G-protein coupled receptor binding
RNA binding
actin binding
protein binding
potassium channel regulator activity
kinase binding
small GTPase binding
Fc-gamma receptor I complex binding
protein homodimerization activity
ion channel binding
macromolecular complex binding
cadherin binding
SMAD binding
actin filament binding
GTPase binding
DNA-binding transcription factor binding
protein sequestering activity
glycoprotein binding
signal transducer activity
protein kinase C binding
transcription factor binding
Rho GTPase binding
Ral GTPase binding
mu-type opioid receptor binding
protein complex binding
poly(A) RNA binding
Rac GTPase binding
epithelial to mesenchymal transition
adenylate cyclase-inhibiting dopamine receptor signaling pathway
biological_process
actin cytoskeleton organization
actin cytoskeleton reorganization
protein localization to cell surface
negative regulation of protein catabolic process
cilium assembly
mRNA transcription from RNA polymerase II promoter
positive regulation of transcription factor import into nucleus
receptor clustering
positive regulation of I-kappaB kinase/NF-kappaB signaling
negative regulation of sequence-specific DNA binding transcription factor activity
early endosome to late endosome transport
establishment of protein localization
protein stabilization
cytoplasmic sequestering of protein
actin crosslink formation
platelet aggregation
mitotic spindle assembly
negative regulation of transcription from RNA polymerase I promoter
cell projection organization
negative regulation of apoptotic process
positive regulation of substrate adhesion-dependent cell spreading
positive regulation of integrin-mediated signaling pathway
blood coagulation, intrinsic pathway
positive regulation of platelet activation
formation of radial glial scaffolds
cerebral cortex development
regulation of cell migration
positive regulation of actin filament bundle assembly
megakaryocyte development
positive regulation of protein import into nucleus
wound healing, spreading of cells
release of sequestered calcium ion into cytosol
cilium morphogenesis
semaphorin-plexin signaling pathway
protein localization to plasma membrane
tubulin deacetylation
establishment of Sertoli cell barrier
positive regulation of potassium ion transmembrane transport
protein localization to bicellular tight junction
regulation of membrane repolarization during atrial cardiac muscle cell action potential
regulation of membrane repolarization during cardiac muscle cell action potential
positive regulation of neural precursor cell proliferation
positive regulation of neuron migration
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support