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Invitrogen
GPRC5D/CD3 (Forimtamig Biosimilar) Recombinant Human Monoclonal Antibody
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Product Details
MA5-54897
Product Specifications
Species Reactivity
Human
Host/Isotype
Human
/ IgG1, kappa/IgG1, lambda
Expression System
CHO cells
Class
Recombinant Monoclonal
Type
Antibody
Immunogen
Recombinant Human GPRC5D and CD3E.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A/G
Storage buffer
PBS
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
RRID
Product Specific Information
Compatible with Direct ELISA
Target Information
GPRC5D is an orphan G protein-coupled receptor belonging to the class C GPCR family. Its physiological ligand and normal biological function are not fully defined. Under normal conditions, GPRC5D expression is limited, with highest levels reported in keratinized tissues such as hair follicles. In oncology, GPRC5D is highly expressed on malignant plasma cells in multiple myeloma, with minimal expression in most other normal tissues. This restricted expression profile has made GPRC5D an attractive therapeutic target for antibody-based therapies and T cell-redirecting approaches, including bispecific antibodies and CAR T cell therapies, in the treatment of relapsed or refractory multiple myeloma.
The CD3 complex, composed of gamma, delta, epsilon, and zeta subunits, is essential for the assembly, trafficking, and surface expression of the T cell receptor (TCR) complex. These subunits are structurally related members of the immunoglobulin superfamily and are encoded by closely linked genes on human chromosome 11. CD3 is expressed by thymocytes in a developmentally regulated manner and by all mature T cells, but not on B or NK cells. The CD3 subunits play a crucial role in transducing antigen-recognition signals into the cytoplasm of T cells. The cytoplasmic tails of CD3 subunits contain a double tyrosine-based motif that associates with cytoplasmic signal transduction molecules, mediating T cell activation through the TCR. Crosslinking of the TCR initiates intracellular biochemical pathways that result in cellular activation, proliferation, and potentially growth arrest and cell survival. CD3 is present on 68-82% of normal peripheral blood lymphocytes, 65-85% of thymocytes, and Purkinje cells in the cerebellum. Decreased percentages of T lymphocytes may be observed in some autoimmune diseases. Defects in the CD3 gene are associated with CD3 immunodeficiency, highlighting its importance in immune function and regulation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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