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Product Details
18175-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Chicken,
Human,
Zebrafish
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Frizzled 10 Fusion Protein Ag12867 (23-229 aa encoded by BC074998)
Conjugate
Form
Liquid
Concentration
0.3 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: SMDMERPGD GKCQPIEIPM CKDIGYNMTR MPNLMGHENQ REAAIQLHEF APLVEYGCHG HLRFFLCSLY APMCTEQVST PIPACRVMCE QARLKCSPIM EQFNFKWPDS LDCRKLPNKN DPNYLCMEAP NNGSDEPTRG SGLFPPLFRP QRPHSAQEHP LKDGGPGRGG CDNPGKFHHV EKSASCAPLC TPGVDVYWSR EDKRFAVV (23-229 aa encoded by BC074998 )
Target Information
FZD10/Frizzled-10 is a 581 amino acid protein belonging to the G-protein coupled receptor Fz/Smo family and containing a signal peptide, a cysteine-rich domain in the N-terminal, seven transmembrane domains and a C-terminal PDZ domain-binding motif. It is involved in transduction, intercellular transmission of polarity information during tissue morphogenesis in differentiated tissues and as a receptor for Wnt proteins. FZD10 is expressed highly in placenta, fetal kidney, fetal lung, brain cerebellum, cerebral cortex, medulla and spinal cord with very low levels in total brain, frontal lobe, temporal lobe, putamen, adult brain, heart, lung and skeletal muscle.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: CD350; CD350 antigen; frizzled 10, seven transmembrane spanning receptor; frizzled family receptor 10; frizzled homolog 10; frizzled homolog 10, pseudogene 1; Frizzled-10; Fz-10; FzE7
Gene Aliases: CD350; FZ-10; Fz10; FZD10; Fzd10-ps1; FzE7; hFz10
UniProt ID: (Human) Q9ULW2, (Mouse) Q8BKG4
Entrez Gene ID: (Human) 11211, (Rat) 363913, (Mouse) 93897
G-protein coupled receptor signaling pathway
neuron differentiation
regulation of actin cytoskeleton organization
negative regulation of GTPase activity
non-canonical Wnt signaling pathway via JNK cascade
positive regulation of JUN kinase activity
positive regulation of GTPase activity
canonical Wnt signaling pathway
cellular response to retinoic acid
biological_process
Wnt signaling pathway
signal transduction
cell surface receptor signaling pathway
multicellular organism development
non-canonical Wnt signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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