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Invitrogen
Fumarase Polyclonal Antibody
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Product Details
PA5-96393
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 45-510 of human FH (NP_0001342)
Conjugate
Form
Liquid
Concentration
0.4 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive Samples: U-87MG, LO2, 22Rv1, NCI-H460, HL-60, NIH/3T3, Mouse heart, Mouse kidney, Rat liver; Cellular Location: Cytoplasm, Mitochondrion
Immunogen sequence: ASQNSFRIEY DTFGELKVPN DKYYGAQTVR STMNFKIGGV TERMPTPVIK AFGILKRAAA EVNQDYGLDP KIANAIMKAA DEVAEGKLND HFPLVVWQTG SGTQTNMNVN EVISNRAIEM LGGELGSKIP VHPNDHVNKS QSSNDTFPTA MHIAAAIEVH EVLLPGLQKL HDALDAKSKE FAQIIKIGRT HTQDAVPLTL GQEFSGYVQQ VKYAMTRIKA AMPRIYELAA GGTAVGTGLN TRIGFAEKVA AKVAALTGLP FVTAPNKFEA LAAHDALVEL SGAMNTTACS LMKIANDIRF LGSGPRSGLG ELILPENEPG SSIMPGKVNP TQCEAMTMVA AQVMGNHVAV TVGGSNGHFE LNVFKPMMIK NVLHSARLLG DASVSFTENC VVGIQANTER INKLMNESLM LVTALNPHIG YDKAAKIAKT AHKNGSTLKE TAIELGYLTA EQFDEWVKPK DMLGPK
Target Information
The protein encoded by this gene is an enzymatic component of the tricarboxylic acid cycle, or Krebs cycle, and catalyzes the formation of L-malate from fumarate. It exists in both a cytosolic form and an N-terminal extended form, differing only in the translation start site used. The N-terminal extended form is targeted to the mitochondrion, where the removal of the extension generates the same form as in the cytoplasm. It is similar to some thermostable class II fumarases and functions as a homotetramer. Mutations in this gene can cause fumarase deficiency and lead to progressive encephalopathy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: EF-3; Fumarase; fumarate hydratase 1; Fumarate hydratase, mitochondrial
Gene Aliases: FH; Fh-1; Fh1; FMRD; HLRCC; LRCC; MCL; MCUL1
UniProt ID: (Human) P07954, (Rat) P14408, (Mouse) P97807
Entrez Gene ID: (Human) 2271, (Rat) 24368, (Mouse) 14194
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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