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|Tested species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||A synthetic peptide made to the human G0S2 protein (residues 1-103).|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS with 0.1% BSA, 50% glycerol|
|Contains||0.05% sodium azide|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
The G(0)-G(1) switch gene 2 (G0S2) codes for a mitochondrial protein that is important in apoptosis, lipolysis, and triaceylglycerol hydrolysis. In adipocytes, G0S2 binds to adipose triglyceride lipase and decreases the breakdown of lipid droplets. In Crohn's colitis, the presence of G0S2 is increased in correlation to the amount of non-converted lipid in waste. In squamous lung cancer, mutations in the G0S2 gene are common. In breast cancer, epigenetic silencing of G0S2 occurs, and normal apoptotic regulation of aberrant cells is negatively impacted. However, when G0S2 is not epigenetically modified, it is the best mediator of the Bcl-2/Bax heterodimer, resulting in apoptosis of cancerous cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
G0/G1 switch regulatory protein 2; G0/G1switch 2; RP1-28O10.2