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Product Details
BS-7611R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human GTSE1/G2 and S phase expressed 1, amino acids 51-150.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
The protein encoded by this gene is only expressed in the S and G2 phases of the cell cycle, where it colocalizes with cytoplasmic tubulin and microtubules. In response to DNA damage, the encoded protein accumulates in the nucleus and binds the tumor suppressor protein p53, shuttling it out of the nucleus and repressing its ability to induce apoptosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: G two S phase expressed protein 1; G-2 and S-phase expressed 1; G2 and S phase-expressed protein 1; GTSE-1; Protein B99; Protein B99 homolog
Gene Aliases: B99; Gtse-1; GTSE1; RGD1563164
UniProt ID: (Human) Q9NYZ3, (Mouse) Q8R080
Entrez Gene ID: (Human) 51512, (Rat) 300126, (Mouse) 29870
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
microtubule-based process
positive regulation of cell migration
proteasome-mediated ubiquitin-dependent protein catabolic process
positive regulation of protein export from nucleus
protein stabilization
positive regulation of protein localization to nucleus
regulation of cell cycle G2/M phase transition
negative regulation of microtubule binding
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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