Glucose-6-phosphatase is an integral membrane protein of the endoplasmic reticulum that catalyzes the hydrolysis of D-glucose 6-phosphate to D-glucose and orthophosphate. It is a key enzyme in glucose homeostasis, functioning in gluconeogenesis and glycogenolysis. Defects in the enzyme cause glycogen storage disease type I.
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Protein Aliases: G-6-Pase; G6Pase-alpha; Glucose-6-phosphatase; Glucose-6-phosphatase alpha; glucose-6-phosphatase, catalytic subunit
Gene Aliases: G6Pase; G6PC; G6PC1; G6PT; GSD1; GSD1a
UniProt ID: (Human) P35575
Entrez Gene ID: (Human) 2538